Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 2/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 15/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.33 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23389579 | 1.00 | DGAT1 (0.38) | DGAT1TGFBR1BRD4CREBBPTGFBR2 | |
| SCHEMBL23389773 | 0.94 | TGFBR1 (0.38) | DGAT1TGFBR1BRD4CREBBPTGFBR2 | |
| SCHEMBL29796722 | 0.94 | TGFBR1 (0.38) | DGAT1TGFBR1BRD4CREBBPTGFBR2 | |
| SCHEMBL29796654 | 0.89 | TGFBR1 (0.34) | DGAT1TGFBR1BRD4CREBBPTGFBR2 | |
| SCHEMBL23389732 | 0.89 | TGFBR1 (0.34) | DGAT1TGFBR1BRD4CREBBPTGFBR2 | |
| SCHEMBL23389954 | 0.88 | TGFBR1 (0.38) | DGAT1TGFBR1BRD4CREBBPTGFBR2 | |
| SCHEMBL29796667 | 0.88 | TGFBR1 (0.38) | DGAT1TGFBR1BRD4CREBBPTGFBR2 | |
| SCHEMBL23389504 | 0.88 | TGFBR1 (0.38) | DGAT1TGFBR1BRD4CREBBPTGFBR2 | |
| SCHEMBL29796627 | 0.88 | TGFBR1 (0.38) | DGAT1TGFBR1BRD4CREBBPTGFBR2 | |
| SCHEMBL23390009 | 0.87 | TGFBR1 (0.34) | DGAT1TGFBR1BRD4CREBBPTGFBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4061809-A1 | SUBSTITUTED 1,5-NAPHTHYRIDINES OR QUINOLINES AS ALK5 INHIBITORS | Theravance Biopharma R&D IP, LLC (US) | 2022-09-28 | — | — | EP | disclosed |
| CN-114728941-A | Substituted 1, 5-naphthyridines or quinolines as ALK5 inhibitors | 施万生物制药研发IP有限责任公司 | 2022-07-08 | — | — | CN | disclosed |