Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 17/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23389738 | 1.00 | KDM4E (0.43) | KDM4ENPC1MAPTRAB9ATGFBR1 | |
| SCHEMBL23408260 | 0.88 | TGFBR1 (0.43) | KDM4ENPC1MAPTRAB9ATGFBR1 | |
| SCHEMBL4875633 | 0.84 | PIK3CD (0.44) | TGFBR1MAPK14 | |
| SCHEMBL29796664 | 0.84 | MAPT (0.39) | KDM4ENPC1MAPTRAB9ATGFBR1 | |
| SCHEMBL23389872 | 0.84 | MAPT (0.39) | KDM4ENPC1MAPTRAB9ATGFBR1 | |
| SCHEMBL25084975 | 0.84 | TGFBR1 (0.42) | TGFBR1MAPK14 | |
| SCHEMBL4859626 | 0.84 | TGFBR1 (0.59) | NPC1RAB9ATGFBR1MAPK14 | |
| SCHEMBL25084720 | 0.82 | CHRNB2 (0.47) | KDM4ETGFBR1 | |
| SCHEMBL4878226 | 0.82 | TGFBR1 (0.59) | TGFBR1MAPK14 | |
| SCHEMBL5789350 | 0.80 | CDK2 (0.44) | KDM4ENPC1MAPTRAB9ATGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4061809-A1 | SUBSTITUTED 1,5-NAPHTHYRIDINES OR QUINOLINES AS ALK5 INHIBITORS | Theravance Biopharma R&D IP, LLC (US) | 2022-09-28 | — | — | EP | disclosed |
| CN-114728941-A | Substituted 1, 5-naphthyridines or quinolines as ALK5 inhibitors | 施万生物制药研发IP有限责任公司 | 2022-07-08 | — | — | CN | disclosed |