Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 8/20 | 0.40 |
| ▸ | THRB | P10828 | 6/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | F12 | P00748 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.37 |
| ▸ | SKP1 | P63208 | 1/20 | 0.37 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.37 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.37 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23389905 | 1.00 | GRM5 (0.42) | GRM5TGFBR1THRBMAPK14F12 | |
| SCHEMBL28785443 | 0.85 | GRM5 (0.47) | GRM5TGFBR1THRBMAPK14TGFBR2 | |
| SCHEMBL16711190 | 0.79 | CSNK1E (0.55) | CSNK1DCSNK1E | |
| SCHEMBL29796492 | 0.78 | GRM5 (0.42) | GRM5TGFBR1CKS1BSKP1SKP2 | |
| SCHEMBL23389963 | 0.78 | GRM5 (0.42) | GRM5TGFBR1CKS1BSKP1SKP2 | |
| SCHEMBL29796602 | 0.78 | GRM5 (0.67) | GRM5 | |
| SCHEMBL23389957 | 0.78 | GRM5 (0.67) | GRM5 | |
| SCHEMBL16711450 | 0.78 | CSNK1E (0.52) | TGFBR1CSNK1DCSNK1E | |
| SCHEMBL26645023 | 0.78 | MERTK (0.43) | GRM5MAPK1CSNK1DCSNK1E | |
| SCHEMBL16730841 | 0.77 | CSNK1E (0.44) | CKS1BSKP1SKP2CSNK1DCSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4061809-A1 | SUBSTITUTED 1,5-NAPHTHYRIDINES OR QUINOLINES AS ALK5 INHIBITORS | Theravance Biopharma R&D IP, LLC (US) | 2022-09-28 | — | — | EP | disclosed |
| CN-114728941-A | Substituted 1, 5-naphthyridines or quinolines as ALK5 inhibitors | 施万生物制药研发IP有限责任公司 | 2022-07-08 | — | — | CN | disclosed |