Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MYC | P01106 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | CCNK | O75909 | 1/20 | 0.34 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.34 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CD38 | P28907 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22895342 | 0.79 | PIM1 (0.38) | MAPTNPC1SMN1; SMN2MYCPIM1 | |
| SCHEMBL6129041 | 0.73 | NPC1 (0.46) | MAPTNPC1SMN1; SMN2MYCPIM1 | |
| SCHEMBL327377 | 0.73 | PIM1 (0.50) | MAPTNPC1SMN1; SMN2PIM1KDM4E | |
| SCHEMBL2345970 | 0.73 | ALDH1A1 (0.69) | MAPTNPC1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL3091105 | 0.72 | PIM1 (0.40) | MAPTPIM1HSP90AA1DYRK1ADYRK2 | |
| SCHEMBL2088047 | 0.70 | PRKCD (0.59) | MAPTNPC1PIM1DYRK1ACHEK1 | |
| SCHEMBL31112110 | 0.70 | MAPK1 (0.40) | CCNKCDK12DYRK1BMEN1KMT2A | |
| SCHEMBL30961277 | 0.69 | CHEK1 (0.35) | MAPTMYCCHEK1CHEK2IMPDH2 | |
| SCHEMBL20455525 | 0.68 | CDK4 (0.49) | MAPTNPC1SMN1; SMN2PIM1MEN1 | |
| SCHEMBL29386286 | 0.68 | CDK4 (0.49) | MAPTNPC1SMN1; SMN2PIM1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022157166-A1 | THIAZOLOPYRIMIDONES AS INHIBITORS OF DDR1/2 AND THERAPEUTIC USES THEREOF | Fundación Del Sector Público Estatal Centro Nacional De Investigaciones Oncológicas Carlos III (F.S.P. CNIO) (ES) | 2022-07-28 | — | — | WO | disclosed |