Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2978126 | 0.97 | GAA (0.41) | GAAL3MBTL1HRH3POLBAKT1 | |
| Hydrochloric Acid SCHEMBL2964835 | 0.96 | GAA (0.41) | GAAL3MBTL1HRH3POLBAKT1 | |
| SCHEMBL2979691 | 0.85 | GAA (0.38) | GAAL3MBTL1HRH3POLBAKT1 | |
| SCHEMBL2979808 | 0.80 | HRH3 (0.39) | GAAL3MBTL1HRH3POLBLMNA | |
| SCHEMBL2979695 | 0.75 | GAA (0.39) | GAAL3MBTL1HRH3POLBHTT | |
| SCHEMBL2979687 | 0.73 | ALDH1A1 (0.35) | GAAL3MBTL1POLBAKT1HTT | |
| SCHEMBL27984492 | 0.69 | SMN1; SMN2 (0.48) | HRH3MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL2978985 | 0.68 | KDM1A (0.43) | POLBTSHRLMNAMAPTMAPK1 | |
| SCHEMBL2978128 | 0.67 | KDM1A (0.43) | HRH3POLBTSHRLMNAMAPT | |
| Hydrochloric Acid SCHEMBL2978982 | 0.67 | KDM1A (0.43) | POLBTSHRLMNAMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776903-B2 | Pharmaceutical preparations containing substituted 2,5-diaminomethyl-1H-pyrroles | GRUENENTHAL GMBH (DE) | 2010-08-17 | — | — | US | claimed |
| EP-1578416-B1 | MEDICAMENTS CONTAINING SUBSTITUTED 2,5-DIAMINOMETHYL-1H-PYRROLES | GRUENENTHAL GMBH (DE) | 2006-08-02 | — | — | EP | claimed |
| US-20050272782-A1 | Pharmaceutical preparations containing substituted 2,5-diaminomethyl-1H-pyrroles | GRUENENTHAL GMBH (DE) | 2005-12-08 | — | — | US | claimed |
| US-7776903-B2 | Pharmaceutical preparations containing substituted 2,5-diaminomethyl-1H-pyrroles | GRUENENTHAL GMBH (DE) | 2010-08-17 | — | — | US | disclosed |
| US-20050272782-A1 | Pharmaceutical preparations containing substituted 2,5-diaminomethyl-1H-pyrroles | GRUENENTHAL GMBH (DE) | 2005-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272782-A1 | Pharmaceutical preparations containing substituted 2,5-diaminomethyl-1H-pyrroles | THPO, ADCYAP1R1, DPYD | GAA 607/4885L3MBTL1 4882/4885HRH3 1443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.