Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2979691 | 0.78 | GAA (0.38) | GAALMNAPOLBMAPK1ALDH1A1 | |
| SCHEMBL2978126 | 0.76 | GAA (0.41) | GAALMNAPOLBMAPK1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL2964835 | 0.75 | GAA (0.41) | GAALMNAPOLBMAPK1ALDH1A1 | |
| SCHEMBL2980038 | 0.75 | GAA (0.42) | GAALMNAPOLBMAPK1ALDH1A1 | |
| SCHEMBL4080149 | 0.66 | GAA (0.47) | GAALMNAALDH1A1KDM4EHTT | |
| SCHEMBL865518 | 0.66 | GAA (0.47) | GAALMNAALDH1A1KDM4EHTT | |
| Hydrochloric Acid SCHEMBL27504935 | 0.65 | LMNA (0.47) | GAALMNAALDH1A1HTTPRKCA | |
| SCHEMBL65358 | 0.65 | ALDH1A1 (0.46) | GAALMNAMAPK1ALDH1A1HSD17B10 | |
| SCHEMBL2978128 | 0.65 | KDM1A (0.43) | LMNAPOLBMAPK1ALDH1A1TSHR | |
| SCHEMBL2963316 | 0.65 | KDM1A (0.45) | GAALMNAPOLBMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776903-B2 | Pharmaceutical preparations containing substituted 2,5-diaminomethyl-1H-pyrroles | GRUENENTHAL GMBH (DE) | 2010-08-17 | — | — | US | claimed |
| EP-1578416-B1 | MEDICAMENTS CONTAINING SUBSTITUTED 2,5-DIAMINOMETHYL-1H-PYRROLES | GRUENENTHAL GMBH (DE) | 2006-08-02 | — | — | EP | claimed |
| US-20050272782-A1 | Pharmaceutical preparations containing substituted 2,5-diaminomethyl-1H-pyrroles | GRUENENTHAL GMBH (DE) | 2005-12-08 | — | — | US | claimed |
| US-7776903-B2 | Pharmaceutical preparations containing substituted 2,5-diaminomethyl-1H-pyrroles | GRUENENTHAL GMBH (DE) | 2010-08-17 | — | — | US | disclosed |
| US-20050272782-A1 | Pharmaceutical preparations containing substituted 2,5-diaminomethyl-1H-pyrroles | GRUENENTHAL GMBH (DE) | 2005-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272782-A1 | Pharmaceutical preparations containing substituted 2,5-diaminomethyl-1H-pyrroles | THPO, ADCYAP1R1, DPYD | GAA 607/4885LMNA 3851/4885POLB 1379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.