Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.65 |
| ▸ | ERN1 | O75460 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 5/20 | 0.64 |
| ▸ | RAB9A | P51151 | 4/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | DRD2 | P14416 | 1/20 | 0.60 |
| ▸ | DRD4 | P21917 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | GFER | P55789 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.58 |
| ▸ | FAAH | O00519 | 1/20 | 0.58 |
| ▸ | KDM1A | O60341 | 1/20 | 0.58 |
| ▸ | GRM5 | P41594 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1928387 | 0.98 | RAB9A (0.67) | PKML3MBTL1USP30ERN1NPC1 | |
| SCHEMBL3037026 | 0.88 | ERN1 (0.65) | PKML3MBTL1ERN1NPC1RAB9A | |
| SCHEMBL16622858 | 0.88 | NPC1 (0.64) | PKMERN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8161568 | 0.85 | NPC1 (0.87) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL6707186 | 0.85 | RAB9A (0.79) | PKML3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9265040 | 0.85 | RAB9A (0.79) | PKML3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL161227 | 0.85 | NPC1 (0.72) | PKML3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14980322 | 0.84 | DRD2 (0.63) | USP30NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL22308180 | 0.84 | NPC1 (0.84) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL22289346 | 0.84 | NPC1 (0.84) | NPC1RAB9ASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781591-B2 | Substituted 3-cyanopyridines as protein kinase inhibitors | WYETH LLC (US) | 2010-08-24 | — | — | US | disclosed |
| US-20070287708-A1 | Substituted 3-cyanopyridines as protein kinase inhibitors | WYETH LLC | 2007-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070287708-A1 | Substituted 3-cyanopyridines as protein kinase inhibitors | CNKSR1, MAP3K1, MAP3K7 | PKM 505/4885L3MBTL1 2322/4885USP30 1726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.