Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.51 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.45 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.44 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22864441 | 1.00 | NR4A2 (0.51) | NR4A2CREBBPMAPTSMN1; SMN2DRD2 | |
| SCHEMBL24814502 | 0.83 | PBRM1 (0.51) | NR4A2CREBBPMAPTSMN1; SMN2HDAC1 | |
| SCHEMBL22864574 | 0.82 | NR4A2 (0.55) | NR4A2MAPTALDH1A1 | |
| SCHEMBL30050333 | 0.81 | HDAC1 (0.50) | NR4A2MAPTSMN1; SMN2HDAC1PBRM1 | |
| SCHEMBL24812437 | 0.81 | HDAC1 (0.50) | NR4A2MAPTSMN1; SMN2HDAC1PBRM1 | |
| SCHEMBL3720163 | 0.80 | ALDH1A1 (0.51) | MAPTSMN1; SMN2HDAC1PBRM1ALDH1A1 | |
| SCHEMBL25139734 | 0.79 | MAPT (0.47) | MAPTSMN1; SMN2HDAC1PBRM1ALDH1A1 | |
| SCHEMBL30390141 | 0.75 | HDAC1 (0.53) | MAPTSMN1; SMN2HDAC1PBRM1ALDH1A1 | |
| SCHEMBL3243758 | 0.73 | HDAC1 (0.55) | MAPTSMN1; SMN2HDAC1PBRM1ALDH1A1 | |
| SCHEMBL3141852 | 0.73 | TSHR (0.44) | MAPTALDH1A1MEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114555585-B | HPK1 inhibitors and uses thereof | 锐格药业公司 | 2025-02-11 | — | — | CN | disclosed |
| CN-114555585-A | HPK1 inhibitors and uses thereof | 上海齐鲁锐格医药研发有限公司 | 2022-05-27 | — | — | CN | disclosed |