Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MGAM | O43451 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SI | P14410 | 1/20 | 0.44 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30390141 | 0.95 | HDAC1 (0.53) | HDAC1ALDH1A1ATMMAPTTP53 | |
| SCHEMBL3720163 | 0.92 | ALDH1A1 (0.51) | HDAC1ALDH1A1ATMMAPTTP53 | |
| SCHEMBL24812437 | 0.78 | HDAC1 (0.50) | HDAC1ALDH1A1ATMMAPTTP53 | |
| SCHEMBL30050333 | 0.78 | HDAC1 (0.50) | HDAC1ALDH1A1ATMMAPTTP53 | |
| SCHEMBL15823052 | 0.77 | LMNA (0.45) | KMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL24814502 | 0.77 | PBRM1 (0.51) | HDAC1ALDH1A1ATMMAPTTP53 | |
| SCHEMBL7837946 | 0.76 | CYP2D6 (0.44) | MAPTMGAMGAASIMGAM2 | |
| SCHEMBL28595479 | 0.74 | MAPT (0.52) | HDAC1ATMMAPTTP53SMN1; SMN2 | |
| SCHEMBL25139734 | 0.73 | MAPT (0.47) | HDAC1ALDH1A1MAPTTP53SMN1; SMN2 | |
| SCHEMBL22864441 | 0.73 | NR4A2 (0.51) | HDAC1ALDH1A1MAPTTP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102204-B1 | NEW AMINOPYRROLO[1,2- A]INDOLE ET AMINOPYRIDAZINO[1,6-A]INDOLE DERIVATIVES, METHOD FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | SERVIER LAB (FR) | 2010-05-05 | — | — | EP | disclosed |
| US-20100105666-A1 | TRIAZABENZO (A)NAPHTHO(2,1,8-CDE) AZULENE COMPOUNDS. | LES LABORATOIRES SERVIER (FR) | 2010-04-29 | — | — | US | disclosed |
| EP-1931341-B1 | 1H-INDOLE-PYRIDINECARBOXAMIDE AND 1H-INDOLE-PIPERIDINECARBOXAMIDE DERIVATIVES AND THEIR USE AS TYROSINE HYDROXYLASE INDUCERS | SERVIER LAB (FR) | 2009-11-04 | — | — | EP | disclosed |
| US-20090258883-A1 | 1H-Indole-Pyridinecarboxamide and 1H-Indole-Piperidinecarboxamide Compounds | LES LABORATOIRES SERVIER (FR) | 2009-10-15 | — | — | US | disclosed |
| EP-2102204-A1 | NEW AMINOPYRROLO[1,2- A]INDOLE ET AMINOPYRIDAZINO[1,6-A]INDOLE DERIVATIVES, METHOD FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | Les Laboratoires Servier (FR) | 2009-09-23 | — | — | EP | disclosed |
| EP-2102209-A2 | NOVEL TRIAZABENZO[A]NAPHTHO[2,L,8-CDE]AZULENE DERIVATIVES, METHOD FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | Les Laboratoires Servier (FR) | 2009-09-23 | — | — | EP | disclosed |
| WO-2009106753-A1 | NOVEL DERIVATIVES OF 1H-INDOL-1-YL UREA, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2009-09-03 | — | — | WO | disclosed |
| EP-2078716-A1 | New derivatives of 1H-indol-1-yl-urea, method for preparing same and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2009-07-15 | — | — | EP | disclosed |
| US-20090176794-A1 | 1H-INDOL-1-YL-UREA COMPOUNDS | LES LABORATOIRES SERVIER (FR) | 2009-07-09 | — | — | US | disclosed |
| CN-101475560-A | New 1H-indol-1-yl-urea compounds, a process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2009-07-08 | — | — | CN | disclosed |
| CN-101257905-A | Novel 1h-indole-pyridinecarboxamide derivatives and 1h-indole-piperidinecarboxamide and their use as hydroxalase tyrosine inducers | SERVIER LAB (FR) | 2008-09-03 | — | — | CN | disclosed |
| WO-2008099081-A2 | NOVEL TRIAZABENZO[Α]NAPHTHO[2,L,8-CDE]AZULENE DERIVATIVES, METHOD FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | LES LABORATOIRES SERVIER (FR) | 2008-08-21 | — | — | WO | disclosed |
| WO-2008099082-A1 | NEW AMINOPYRROLO[1,2-Α]INDOLE ET AMINOPYRIDAZINO[1,6-Α]INDOLE DERIVATIVES, METHOD FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | LES LABORATOIRES SERVIER (FR) | 2008-08-21 | — | — | WO | disclosed |
| EP-1931341-A2 | NOVEL 1H-INDOLE-PYRIDINECARBOXAMIDE DERIVATIVES AND 1H-INDOLE-PIPERIDINECARBOXAMIDE AND THEIR USE AS HYDROXALASE TYROSINE INDUCERS | Les Laboratoires Servier (FR) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007006922-A2 | NOVEL 1H-INDOLE-PYRIDINECARBOXAMIDE DERIVATIVES AND 1H-INDOLE-PIPERIDINECARBOXAMIDE AND THEIR USE AS HYDROXYLASE TYROSINE INDUCERS | LES LABORATOIRES SERVIER (FR) | 2007-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105666-A1 | TRIAZABENZO (A)NAPHTHO(2,1,8-CDE) AZULENE COMPOUNDS. | NR1I2, NR2E1, NR0B2 | HDAC1 921/4885ALDH1A1 1020/4885ATM 3873/4885 |
| US-20090176794-A1 | 1H-INDOL-1-YL-UREA COMPOUNDS | TPH1, HTR1D, IDO1 | HDAC1 1453/4885ALDH1A1 439/4885ATM 3589/4885 |
| US-20090258883-A1 | 1H-Indole-Pyridinecarboxamide and 1H-Indole-Piperidinecarboxamide Compounds | IDO1, AHR, IDO2 | HDAC1 595/4885ALDH1A1 370/4885ATM 3509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.