Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 8/20 | 0.45 |
| ▸ | TSHR | P16473 | 7/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 3/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23135998 | 0.88 | DPP4 (0.49) | CCR1CYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL23137089 | 0.82 | ATM (0.49) | CYP3A4CYP2C9TSHRCYP2C19ALDH1A1 | |
| SCHEMBL6586747 | 0.77 | HRH1 (0.50) | CCR1CYP3A4TSHROPRK1ATM | |
| SCHEMBL23856080 | 0.73 | HRH1 (0.57) | CCR1OPRK1CTSK | |
| SCHEMBL23856082 | 0.73 | HRH1 (0.57) | CCR1OPRK1CTSK | |
| SCHEMBL938009 | 0.73 | ATM (0.57) | ATMCTSKCTSLCTSB | |
| SCHEMBL938011 | 0.73 | ATM (0.57) | ATMCTSKCTSLCTSB | |
| SCHEMBL15414625 | 0.73 | ATM (0.57) | ATMCTSKCTSLCTSB | |
| SCHEMBL5268187 | 0.72 | ATM (0.59) | CYP3A4CYP2C9CYP2C19ALDH1A1LMNA | |
| SCHEMBL6407665 | 0.72 | ATM (0.59) | CYP3A4CYP2C9CYP2C19LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4031542-B1 | SMALL MOLECULE INHIBITORS OF KRAS G12C MUTANT | MERCK SHARP & DOHME LLC (US) | 2025-10-15 | — | — | EP | disclosed |
| US-20220402916-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12C MUTANT | MERCK SHARP & DOHME CORP. | 2022-12-22 | — | — | US | disclosed |
| EP-4031542-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12C MUTANT | MERCK SHARP & DOHME CORP. (US) | 2022-07-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220402916-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12C MUTANT | KRAS, NRAS, HRAS | CCR1 2698/4885CYP3A4 4456/4885CYP2C9 3285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.