Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | PPARG | P37231 | 5/20 | 0.47 |
| ▸ | PPARA | Q07869 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4035030 | 0.84 | HRH3 (0.57) | KDM4EHRH3HPGDPPARGPPARA | |
| SCHEMBL22630335 | 0.84 | HSD17B10 (0.50) | KDM4EHPGDPPARARAB9ANPC1 | |
| SCHEMBL5099115 | 0.84 | TARBP2 (0.47) | KDM4EHRH3HPGDPPARGPPARA | |
| SCHEMBL1758572 | 0.84 | KDM4E (0.63) | KDM4EHRH3HPGDPPARGPPARA | |
| SCHEMBL5726983 | 0.84 | KDM4E (0.59) | KDM4EHRH3HPGDPPARGPPARA | |
| SCHEMBL14736616 | 0.83 | USP1 (0.45) | KDM4EHRH3HPGDRAB9ANPC1 | |
| SCHEMBL5103005 | 0.83 | RXFP1 (0.49) | KDM4EPPARGPPARARAB9ANPC1 | |
| SCHEMBL9096448 | 0.82 | ALDH1A1 (0.50) | KDM4ERAB9ANPC1LMNAKMT2A | |
| SCHEMBL13722410 | 0.81 | KDM4E (0.56) | KDM4EHRH3HPGDPPARGPPARA | |
| SCHEMBL5759578 | 0.81 | KDM4E (0.47) | KDM4EPPARGPPARARAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772264-B2 | Salt and polymorphs of a DPPIV inhibitor | HOFFMANN-LA ROCHE INC. (US) | 2010-08-10 | — | — | US | disclosed |
| US-7772264-B2 | Salt and polymorphs of a DPPIV inhibitor | HOFFMANN-LA ROCHE INC. (US) | 2010-08-10 | — | — | US | disclosed |
| US-7772264-B2 | Salt and polymorphs of a DPPIV inhibitor | HOFFMANN-LA ROCHE INC. (US) | 2010-08-10 | — | — | US | disclosed |
| CN-101146801-A | Novel salts and polymorphs of a DPP-IV inhibitor | HOFFMANN LA ROCHE (CH) | 2008-03-19 | — | — | CN | disclosed |
| EP-1888571-A2 | NEW SALT AND POLYMORPHS OF A DPP-IV INHIBITOR | F. Hoffmann-Roche AG (CH) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006108491-A1 | IMPROVED PROCESS FOR PREPARING OXAZOLE NITRILES | DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG (AT) | 2006-10-19 | — | — | WO | disclosed |
| US-20060217428-A1 | Salt and polymorphs of a DPPIV inhibitor | HOFFMANN-LA ROCHE INC. | 2006-09-28 | — | — | US | disclosed |
| WO-2006100181-A2 | NEW SALT AND POLYMORPHS OF A DPP-IV INHIBITOR | F. HOFFMANN-LA ROCHE AG (CH) | 2006-09-28 | — | — | WO | disclosed |
| WO-2006100181-A2 | NEW SALT AND POLYMORPHS OF A DPP-IV INHIBITOR | F. HOFFMANN-LA ROCHE AG (CH) | 2006-09-28 | — | — | WO | disclosed |
| WO-2006041921-A2 | PREPARATION AND USES OF RHODANINE DERIVATIVES | AUSPEX PHARMACEUTICALS, INC. (US) | 2006-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060217428-A1 | Salt and polymorphs of a DPPIV inhibitor | DPP4, DPP3, DPP9 | KDM4E 1304/4885HRH3 3570/4885HPGD 2438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.