Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 2/20 | 0.45 |
| ▸ | NAE1 | Q13564 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 3/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2980622 | 0.87 | NR4A2 (0.46) | ULK1NAE1JAK2NOTUMEGFR | |
| SCHEMBL4246552 | 0.86 | NAE1 (0.51) | ULK1NAE1JAK2NOTUMEGFR | |
| SCHEMBL2989022 | 0.85 | JAK2 (0.41) | ULK1NAE1JAK2NOTUMEGFR | |
| SCHEMBL2984052 | 0.85 | JAK2 (0.41) | ULK1NAE1JAK2NOTUMEGFR | |
| SCHEMBL2975051 | 0.84 | HTR1A (0.50) | ULK1NAE1JAK2NOTUMEGFR | |
| SCHEMBL17255750 | 0.84 | EGFR (0.44) | ULK1NAE1JAK2NOTUMEGFR | |
| SCHEMBL2983509 | 0.83 | HTR1A (0.51) | JAK2 | |
| SCHEMBL17255760 | 0.83 | LTA4H (0.45) | JAK2NOTUMEGFRERBB2PRKCQ | |
| SCHEMBL17255759 | 0.82 | HTR1A (0.46) | JAK2EGFRSYKPRKCQFLT1 | |
| SCHEMBL17255756 | 0.81 | EGFR (0.42) | ULK1NAE1JAK2EGFRSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781591-B2 | Substituted 3-cyanopyridines as protein kinase inhibitors | WYETH LLC (US) | 2010-08-24 | — | — | US | claimed |