SCHEMBL29809286

SCHEMBL29809286

Cn1ccc2cc(F)ccc2c1=O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.43
CDK4 P11802 3/20 0.41
CCND1 P24385 3/20 0.41
CCNE2 O96020 2/20 0.41
CCNE1 P24864 2/20 0.41
CDK2 P24941 2/20 0.41
BRD4 O60885 5/20 0.41
BRD9 Q9H8M2 2/20 0.41
TAF1 P21675 1/20 0.41
BRPF1 P55201 1/20 0.41
CREBBP Q92793 1/20 0.41
CECR2 Q9BXF3 1/20 0.41
ATM Q13315 1/20 0.40
HTR6 P50406 1/20 0.38
KCNH2 Q12809 1/20 0.38
KDM4E B2RXH2 2/20 0.37
ALDH1A1 P00352 2/20 0.37
HPGD P15428 1/20 0.37
HSD17B10 Q99714 1/20 0.37
FEN1 P39748 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5312359 1.00 ALOX5 (0.43) ALOX5CDK4CCND1CCNE2CCNE1
SCHEMBL9919030 0.85 CDK4 (0.43) CDK4CCND1CCNE2CCNE1CDK2
SCHEMBL30617770 0.79 BRD4 (0.42) ALOX5CDK4CCND1CCNE2CCNE1
SCHEMBL7601676 0.79 MEN1 (0.49) CDK4CCND1CCNE2CCNE1CDK2
SCHEMBL12177181 0.79 BRD9 (0.42) ALOX5CDK2BRD4BRD9TAF1
SCHEMBL29809554 0.79 MEN1 (0.49) CDK4CCND1CCNE2CCNE1CDK2
SCHEMBL23346719 0.78 PRKCI (0.56) CDK2BRD4BRD9TAF1BRPF1
SCHEMBL582859 0.78 CCNE2 (0.41) CDK4CCND1CCNE2CCNE1CDK2
SCHEMBL9919031 0.78 BRD9 (0.41) BRD4BRD9TAF1BRPF1CREBBP
SCHEMBL29809118 0.78 CCNE2 (0.41) CDK4CCND1CCNE2CCNE1CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114805204-A Method for preparing 4-iodoisoquinoline-1 (2H) -ketone compound 云南师范大学 2022-07-29 CN claimed
CN-114805204-B Method for preparing 4-iodoisoquinoline-1 (2H) -ketone compound 云南师范大学 2023-09-15 CN disclosed
CN-114805204-A Method for preparing 4-iodoisoquinoline-1 (2H) -ketone compound 云南师范大学 2022-07-29 CN disclosed