Sugi Predict

Sugi Predict / Compounds / SCHEMBL582859

SCHEMBL582859

SCHEMBL582859

Cn1ccc2cc(Br)ccc2c1=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CCNE2 O96020 1/20 0.41
▸ CDK4 P11802 1/20 0.41
▸ CCND1 P24385 1/20 0.41
▸ CCNE1 P24864 1/20 0.41
▸ CDK2 P24941 1/20 0.41
▸ BRD9 Q9H8M2 2/20 0.41
▸ BRD4 O60885 1/20 0.41
▸ TAF1 P21675 1/20 0.41
▸ BRPF1 P55201 1/20 0.41
▸ CREBBP Q92793 1/20 0.41
▸ CECR2 Q9BXF3 1/20 0.41
▸ ERN1 O75460 1/20 0.38
▸ MCL1 Q07820 1/20 0.37
▸ CASP3 P42574 1/20 0.36
▸ KDM4E B2RXH2 1/20 0.36
▸ ALDH1A1 P00352 1/20 0.36
▸ MAPT P10636 1/20 0.36
▸ GAA P10253 1/20 0.36
▸ NCEH1 Q6PIU2 2/20 0.36
▸ HPGD P15428 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29809118 1.00 CCNE2 (0.41) CCNE2CDK4CCND1CCNE1CDK2
SCHEMBL9919029 0.85 PSMB1 (0.46) CCNE2CDK4CCND1CCNE1CDK2
SCHEMBL7601676 0.79 MEN1 (0.49) CCNE2CDK4CCND1CCNE1CDK2
SCHEMBL29809554 0.79 MEN1 (0.49) CCNE2CDK4CCND1CCNE1CDK2
SCHEMBL12177181 0.79 BRD9 (0.42) CDK2BRD9BRD4TAF1BRPF1
SCHEMBL6923560 0.78 GRM2 (0.55) HTR2AHTR2CPSMB1PSMB5
SCHEMBL23346719 0.78 PRKCI (0.56) CDK2BRD9BRD4TAF1BRPF1
SCHEMBL29809286 0.78 ALOX5 (0.43) CCNE2CDK4CCND1CCNE1CDK2
SCHEMBL9919031 0.78 BRD9 (0.41) BRD9BRD4TAF1BRPF1CREBBP
SCHEMBL5312359 0.78 ALOX5 (0.43) CCNE2CDK4CCND1CCNE1CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 113 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4134364-B1 BROMODOMAIN INHIBITORS CELGENE QUANTICEL RES INC (US) 2025-07-30 — — EP disclosed
US-20250136592-A1 C-LINKED INHIBITORS OF ENL/AF9 YEATS BRIDGE MEDICINES 2025-05-01 — — US disclosed
CN-119707930-A Aromatic ring compound and its prepn and use 甘李药业股份有限公司 2025-03-28 — — CN disclosed
US-20250034134-A1 15-PGDH INHIBITOR AND USE THEREOF Wuhan Humanwell Innovative Drug Research and Development Center Limited Company (CN) 2025-01-30 — — US disclosed
EP-4434986-A1 15-PGDH INHIBITOR AND USE THEREOF Wuhan Humanwell Innovative Drug Research and Development Center Limited Company (CN) 2024-09-25 — — EP disclosed
US-20240182490-A1 BROMODOMAIN INHIBITORS CELGENE QUANTICEL RESEARCH, INC. (US) 2024-06-06 — — US disclosed
US-20240150328-A1 METHODS AND COMPOUNDS FOR TREATING DISORDERS FOGHORN THERAPEUTICS INC. 2024-05-09 — — US disclosed
CN-117858877-A C-linked inhibitors of ENL/AF9 YEATS 桥梁药品有限公司 2024-04-09 — — CN disclosed
EP-4337662-A1 C-LINKED INHIBITORS OF ENL/AF9 YEATS Bridge Medicines (US) 2024-03-20 — — EP disclosed
EP-4313967-A1 KHK INHIBITORS GILEAD SCIENCES, INC. (US) 2024-02-07 — — EP disclosed
EP-2416660-B1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS INC (US) 2014-07-02 — — EP disclosed
US-20130345173-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS, INC. (US) 2013-12-26 — — US disclosed
US-8546564-B2 Inhibitors of fatty acid amide hydrolase INFINITY PHARMACEUTICALS, INC. (US) 2013-10-01 — — US disclosed
US-20120094957-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS INC. 2012-04-19 — — US disclosed
EP-2416660-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE Infinity Pharmaceuticals, Inc. (US) 2012-02-15 — — EP disclosed
US-20110160208-A1 DIARYL-SUBSTITUTED FIVE-MEMBERED HETEROCYCLE DERIVATIVE BANYU PHARMACEUTICAL CO., LTD. (JP) 2011-06-30 — — US disclosed
US-7902369-B2 Diaryl-substituted five-membered heterocycle derivative BANYU PHARMACEUTICAL CO., LTD. (JP) 2011-03-08 — — US disclosed
WO-2010118155-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS, INC. (US) 2010-10-14 — — WO disclosed
US-20070173507-A1 Dairyl-substituted five-membered heterocycle derivative MSD K.K. (JP) 2007-07-26 — — US disclosed
EP-1726585-A1 DIARYL-SUBSTITUTED FIVE-MEMBERED HETEROCYCLE DERIVATIVE BANYU PHARMACEUTICAL CO., LTD. (JP) 2006-11-29 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110160208-A1 DIARYL-SUBSTITUTED FIVE-MEMBERED HETEROCYCLE DERIVATIVE OPRK1, GRM1, GRIK1 CCNE2 2192/4885CDK4 440/4885CCND1 1585/4885
US-20070173507-A1 Dairyl-substituted five-membered heterocycle derivative OPRK1, OPRL1, GRM1 CCNE2 1669/4885CDK4 200/4885CCND1 1216/4885
US-20240182490-A1 BROMODOMAIN INHIBITORS BRD3, EP300, BRPF3 CCNE2 1952/4885CDK4 305/4885CCND1 1172/4885
US-20130345173-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE FAAH, FAAH2, FFAR3 CCNE2 2786/4885CDK4 3547/4885CCND1 2625/4885
US-20250034134-A1 15-PGDH INHIBITOR AND USE THEREOF HPGD, UGDH, PGD CCNE2 2742/4885CDK4 2372/4885CCND1 1589/4885
US-20120094957-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE FAAH, FAAH2, FFAR3 CCNE2 2785/4885CDK4 3507/4885CCND1 2574/4885
US-20240150328-A1 METHODS AND COMPOUNDS FOR TREATING DISORDERS VHL, TFEB, BECN1 CCNE2 3930/4885CDK4 794/4885CCND1 4560/4885
US-20250136592-A1 C-LINKED INHIBITORS OF ENL/AF9 YEATS MLLT3, MLLT1, YEATS2 CCNE2 2957/4885CDK4 1155/4885CCND1 2368/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.