Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.40 |
| ▸ | MEN1 | O00255 | 8/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | BRAF | P15056 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23496853 | 1.00 | ALDH1A1 (0.47) | ALDH1A1NPC1RAB9AALOX15MAPK1 | |
| SCHEMBL24718536 | 0.89 | ALDH1A1 (0.52) | ALDH1A1NPC1RAB9AALOX15MAPK1 | |
| SCHEMBL25643115 | 0.86 | ALDH1A1 (0.47) | ALDH1A1NPC1RAB9AALOX15MAPK1 | |
| SCHEMBL23496851 | 0.85 | ALDH1A1 (0.38) | ALDH1A1NPC1RAB9AMAPK1KMT2A | |
| SCHEMBL30078401 | 0.85 | ALDH1A1 (0.38) | ALDH1A1NPC1RAB9AMAPK1KMT2A | |
| SCHEMBL23498289 | 0.84 | MEN1 (0.36) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL30781859 | 0.84 | ALDH1A1 (0.47) | ALDH1A1NPC1RAB9AALOX15MAPK1 | |
| SCHEMBL27100883 | 0.84 | ALDH1A1 (0.47) | ALDH1A1NPC1RAB9AALOX15MAPK1 | |
| SCHEMBL29812974 | 0.84 | MEN1 (0.36) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL30014245 | 0.83 | ALDH1A1 (0.47) | ALDH1A1NPC1RAB9AALOX15MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260083750-A1 | SMALL MOLECULE INHIBITORS OF KRAS PROTEINS | MERCK SHARP & DOHME LLC | 2026-03-26 | — | — | US | disclosed |
| US-12528828-B2 | Substituted pyrido[4,3-d]pyrimidines as KRAS modulators | ALTEROME THERAPEUTICS, INC. (US) | 2026-01-20 | — | — | US | disclosed |
| US-20250346610-A1 | SUBSTITUTED PYRIDO[4,3-d]PYRIMIDINES AS KRAS MODULATORS | ALTEROME THERAPEUTICS INC (US) | 2025-11-13 | — | — | US | disclosed |
| EP-4640684-A1 | KRAS G12D INHIBITORS AND USES THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2025-10-29 | — | — | EP | disclosed |
| EP-4577214-A2 | SMALL MOLECULE INHIBITORS OF KRAS PROTEINS | Merck Sharp & Dohme LLC (US) | 2025-07-02 | — | — | EP | disclosed |
| US-20250179093-A1 | KRAS MODULATORS | ALTEROME THERAPEUTICS, INC. | 2025-06-05 | — | — | US | disclosed |
| CN-119894891-A | KRAS G12D inhibitor and application thereof | 上海和誉生物医药科技有限公司 | 2025-04-25 | — | — | CN | disclosed |
| WO-2025077663-A1 | FUSED RING COMPOUND AND USE | 成都海博为药业有限公司 | 2025-04-17 | — | — | WO | disclosed |
| WO-2025077770-A1 | FUSED RING COMPOUND AND USE THEREOF IN KRAS INHIBITOR | 成都海博为药业有限公司 | 2025-04-17 | — | — | WO | disclosed |
| WO-2025064542-A1 | KRAS MODULATORS | ALTEROME THERAPEUTICS, INC. (US) | 2025-03-27 | — | — | WO | disclosed |
| EP-4436571-A1 | SMALL MOLECULE INHIBITORS OF KRAS MUTATED PROTEINS | Merck Sharp & Dohme LLC (US) | 2024-10-02 | — | — | EP | disclosed |
| WO-2024131827-A1 | KRAS G12D INHIBITORS AND USES THEREOF | 上海和誉生物医药科技有限公司 | 2024-06-27 | — | — | WO | disclosed |
| CN-117820333-A | KRAS G12C inhibitors | 伊莱利利公司 | 2024-04-05 | — | — | CN | disclosed |
| WO-2024044667-A2 | SMALL MOLECULE INHIBITORS OF KRAS PROTEINS | MERCK SHARP & DOHME LLC (US) | 2024-02-29 | — | — | WO | disclosed |
| CN-117500799-A | Substituted fused azines as KRAS G12D inhibitors | 伊莱利利公司 | 2024-02-02 | — | — | CN | disclosed |
| CN-114828964-B | KRAS G12C inhibitors | 伊莱利利公司 | 2023-11-24 | — | — | CN | disclosed |
| WO-2023097227-A1 | SMALL MOLECULE INHIBITORS OF KRAS MUTATED PROTEINS | MERCK SHARP & DOHME LLC (US) | 2023-06-01 | — | — | WO | disclosed |
| CN-114828964-A | KRAS G12C inhibitors | 伊莱利利公司 | 2022-07-29 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250179093-A1 | KRAS MODULATORS | KRAS, NRAS, HRAS | ALDH1A1 4071/4885NPC1 2198/4885RAB9A 96/4885 |
| US-20250346610-A1 | SUBSTITUTED PYRIDO[4,3-d]PYRIMIDINES AS KRAS MODULATORS | KRAS, NRAS, HRAS | ALDH1A1 3593/4885NPC1 3624/4885RAB9A 105/4885 |
| US-20260083750-A1 | SMALL MOLECULE INHIBITORS OF KRAS PROTEINS | KRAS, NRAS, RASGRP1 | ALDH1A1 3539/4885NPC1 2120/4885RAB9A 16/4885 |
| US-12528828-B2 | Substituted pyrido[4,3-d]pyrimidines as KRAS modulators | KRAS, NRAS, HRAS | ALDH1A1 1854/4885NPC1 1122/4885RAB9A 88/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.