Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 2/20 | 1.00 |
| ▸ | TLR1 | Q15399 | 2/20 | 1.00 |
| ▸ | TLR6 | Q9Y2C9 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 6/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 8/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | G6PD | P11413 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28982449 | 1.00 | TLR2 (1.00) | TLR2TLR1TLR6LMNAALDH1A1 | |
| SCHEMBL13187231 | 1.00 | TLR2 (1.00) | TLR2TLR1TLR6LMNAALDH1A1 | |
| SCHEMBL10090691 | 0.81 | AKR1C3 (0.70) | TLR2TLR1TLR6LMNAALDH1A1 | |
| SCHEMBL6009783 | 0.81 | SMN1; SMN2 (0.76) | TLR2TLR1TLR6LMNAALDH1A1 | |
| SCHEMBL524859 | 0.81 | SMN1; SMN2 (0.76) | TLR2TLR1TLR6LMNAALDH1A1 | |
| SCHEMBL13187253 | 0.78 | TLR2 (0.64) | TLR2TLR1TLR6LMNAALDH1A1 | |
| SCHEMBL17810910 | 0.76 | MAPT (0.69) | TLR2TLR1TLR6LMNAALDH1A1 | |
| SCHEMBL17810912 | 0.76 | MAPT (0.69) | TLR2TLR1TLR6LMNAALDH1A1 | |
| SCHEMBL17826053 | 0.76 | MAPT (0.69) | TLR2TLR1TLR6LMNAALDH1A1 | |
| SCHEMBL11413775 | 0.76 | TLR2 (0.62) | TLR2TLR1TLR6LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114848620-B | Use of TLR2 inhibitors in combination with FOLFOX in the treatment of colorectal cancer | 上海交通大学医学院附属瑞金医院 | 2024-02-09 | — | — | CN | disclosed |
| CN-116672331-A | Application of Toll-like receptor 2 inhibitor in preparation of medicine for treating chronic migraine | 兰州大学第二医院 | 2023-09-01 | — | — | CN | disclosed |
| CN-114848620-A | Use of a TLR2 inhibitor in combination with FOLFOX in the treatment of colorectal cancer | 上海交通大学医学院附属瑞金医院 | 2022-08-05 | — | — | CN | disclosed |