Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 2/20 | 1.00 |
| ▸ | TLR1 | Q15399 | 2/20 | 1.00 |
| ▸ | TLR6 | Q9Y2C9 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 6/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 8/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | G6PD | P11413 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28982449 | 1.00 | TLR2 (1.00) | TLR2TLR1TLR6LMNAALDH1A1 | |
| SCHEMBL29819638 | 1.00 | TLR2 (1.00) | TLR2TLR1TLR6LMNAALDH1A1 | |
| SCHEMBL10090691 | 0.81 | AKR1C3 (0.70) | TLR2TLR1TLR6LMNAALDH1A1 | |
| SCHEMBL6009783 | 0.81 | SMN1; SMN2 (0.76) | TLR2TLR1TLR6LMNAALDH1A1 | |
| SCHEMBL524859 | 0.81 | SMN1; SMN2 (0.76) | TLR2TLR1TLR6LMNAALDH1A1 | |
| SCHEMBL13187253 | 0.78 | TLR2 (0.64) | TLR2TLR1TLR6LMNAALDH1A1 | |
| SCHEMBL17810910 | 0.76 | MAPT (0.69) | TLR2TLR1TLR6LMNAALDH1A1 | |
| SCHEMBL17810912 | 0.76 | MAPT (0.69) | TLR2TLR1TLR6LMNAALDH1A1 | |
| SCHEMBL17826053 | 0.76 | MAPT (0.69) | TLR2TLR1TLR6LMNAALDH1A1 | |
| SCHEMBL11413775 | 0.76 | TLR2 (0.62) | TLR2TLR1TLR6LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180110746-A1 | SMALL MOLECULE INHIBITORS OF TLR2 SIGNALING | UNIVERSITY OF MARYLAND, BALTIMORE | 2018-04-26 | — | — | US | disclosed |
| US-20180110746-A1 | SMALL MOLECULE INHIBITORS OF TLR2 SIGNALING | UNIVERSITY OF MARYLAND, BALTIMORE | 2018-04-26 | — | — | US | disclosed |
| WO-2010053606-A9 | SMALL-MOLECULE INHIBITORS OF PROTEIN SYNTHESIS INACTIVATING TOXINS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2010-09-02 | — | — | WO | disclosed |
| WO-2010053606-A2 | SMALL-MOLECULE INHIBITORS OF PROTEIN SYNTHESIS INACTIVATING TOXINS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2010-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180110746-A1 | SMALL MOLECULE INHIBITORS OF TLR2 SIGNALING | TLR2, TLR1, TLR6 | TLR2 1/4885TLR1 2/4885TLR6 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.