Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 1/20 | 0.56 |
| ▸ | SKP1 | P63208 | 1/20 | 0.56 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.56 |
| ▸ | JAK1 | P23458 | 5/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | SUV39H2 | Q9H5I1 | 3/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 2/20 | 0.43 |
| ▸ | SMO | Q99835 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 3/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.41 |
| ▸ | ITGAL | P20701 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22766247 | 1.00 | CKS1B (0.56) | CKS1BSKP1SKP2JAK1RET | |
| SCHEMBL22576432 | 0.84 | CKS1B (0.42) | CKS1BSKP1SKP2JAK1JAK2 | |
| SCHEMBL22734970 | 0.80 | CKS1B (0.50) | CKS1BSKP1SKP2JAK1RET | |
| SCHEMBL29974041 | 0.80 | CKS1B (0.50) | CKS1BSKP1SKP2JAK1RET | |
| SCHEMBL22576378 | 0.80 | CKS1B (0.53) | CKS1BSKP1SKP2RET | |
| SCHEMBL30501971 | 0.80 | CKS1B (0.53) | CKS1BSKP1SKP2RET | |
| SCHEMBL30931884 | 0.77 | CKS1B (0.61) | CKS1BSKP1SKP2RETJAK3 | |
| SCHEMBL7080374 | 0.77 | CKS1B (0.61) | CKS1BSKP1SKP2RETJAK3 | |
| SCHEMBL530038 | 0.77 | CKS1B (0.61) | CKS1BSKP1SKP2RETJAK3 | |
| SCHEMBL21564581 | 0.77 | CKS1B (0.61) | CKS1BSKP1SKP2RETJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3728253-B1 | 6-AZAINDOLE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2024-03-27 | — | — | EP | disclosed |
| US-11912703-B2 | 6-azaindole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-02-27 | — | — | US | disclosed |
| CN-111699185-B | 6-azaindole compounds | 百时美施贵宝公司 | 2023-06-27 | — | — | CN | disclosed |
| US-20220348576-A1 | 6-AZAINDOLE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2022-11-03 | — | — | US | disclosed |
| US-11427580-B2 | 6-azaindole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11912703-B2 | 6-azaindole compounds | TLR7, TLR9, TLR5 | CKS1B 2255/4885SKP1 2197/4885SKP2 3261/4885 |
| US-20220348576-A1 | 6-AZAINDOLE COMPOUNDS | TLR7, TLR9, TLR5 | CKS1B 2255/4885SKP1 2197/4885SKP2 3261/4885 |
| US-11427580-B2 | 6-azaindole compounds | TLR7, TLR9, TLR5 | CKS1B 2255/4885SKP1 2197/4885SKP2 3261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.