Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.47 |
| ▸ | ALDH3A1 | P30838 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | IDH2 | P48735 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25782081 | 1.00 | PTPN1 (0.49) | PTPN1LMNASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL13881915 | 0.83 | LMNA (0.55) | LMNASMN1; SMN2ALDH1A1MEN1POLB | |
| SCHEMBL23592047 | 0.83 | L3MBTL1 (0.55) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL29824728 | 0.83 | L3MBTL1 (0.55) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL22718133 | 0.83 | EPAS1 (0.50) | ALDH1A1MEN1KMT2AMAPTEPAS1 | |
| SCHEMBL22718149 | 0.81 | IDH2 (0.46) | LMNAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL22747361 | 0.80 | SCN9A (0.54) | — | |
| SCHEMBL22718161 | 0.80 | IDH2 (0.50) | MEN1POLBKMT2AMAPTEPAS1 | |
| SCHEMBL29602571 | 0.80 | IDH2 (0.50) | MEN1POLBKMT2AMAPTEPAS1 | |
| SCHEMBL22747371 | 0.79 | IDH2 (0.47) | MAPTEPAS1CYP2C9IDH2NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4081202-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | Dana-Farber Cancer Institute, Inc. (US) | 2022-11-02 | — | — | EP | disclosed |
| CN-115103670-A | Transcription Enhancement Associated Domain (TEAD) transcription factor inhibitors and uses thereof | 达纳-法伯癌症研究所股份有限公司 | 2022-09-23 | — | — | CN | disclosed |