Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 15/20 | 1.00 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.51 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | C1R | P00736 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21776812 | 1.00 | NOTUM (1.00) | NOTUMPDK2PSMB8HSD11B1C1R | |
| SCHEMBL3586821 | 0.83 | NOTUM (1.00) | NOTUMPDK2 | |
| SCHEMBL3858284 | 0.82 | NOTUM (0.70) | NOTUMPDK2 | |
| SCHEMBL28844973 | 0.82 | NOTUM (0.70) | NOTUMPDK2 | |
| SCHEMBL7050954 | 0.76 | NOTUM (1.00) | NOTUMPDK2 | |
| SCHEMBL22556460 | 0.72 | NOTUM (0.56) | NOTUMPDK2 | |
| SCHEMBL29888460 | 0.72 | NOTUM (0.56) | NOTUMPDK2 | |
| SCHEMBL4752346 | 0.72 | NOTUM (1.00) | NOTUMPDK2 | |
| SCHEMBL21061962 | 0.72 | NOTUM (0.61) | NOTUMPDK2 | |
| SCHEMBL4276979 | 0.72 | NOTUM (0.70) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11634391-B2 | Compounds which are inhibitors of Notum | UCL BUSINESS LTD (GB) | 2023-04-25 | — | — | US | disclosed |
| WO-2022180080-A1 | ANTI-PROLIFERATIVE AGENTS | FIRST HEALTH PHARMACEUTICALS B.V. (NL) | 2022-09-01 | — | — | WO | disclosed |
| EP-4050002-A1 | ANTI-PROLIFERATIVE AGENTS | First Health Pharmaceuticals B.V. (NL) | 2022-08-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11634391-B2 | Compounds which are inhibitors of Notum | NOTUM, GOT2, GOT1 | NOTUM 1/4885PDK2 698/4885PSMB8 3485/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.