Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 3/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.47 |
| ▸ | PDE2A | O00408 | 2/20 | 0.47 |
| ▸ | PDE6D | O43924 | 1/20 | 0.47 |
| ▸ | PDE6A | P16499 | 1/20 | 0.47 |
| ▸ | PDE6G | P18545 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE6B | P35913 | 1/20 | 0.47 |
| ▸ | PDE6C | P51160 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.47 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29829591 | 0.87 | CASR (0.60) | CASRPDE6DTLR8TP53SIGMAR1 | |
| SCHEMBL29829518 | 0.84 | CASR (0.60) | CASRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29829974 | 0.83 | CASR (0.53) | CASRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29829696 | 0.81 | TLR8 (0.51) | CASRPDE10ATLR8SIGMAR1LMNA | |
| SCHEMBL29412030 | 0.79 | CASR (0.47) | CASRMEN1KMT2A | |
| SCHEMBL28903065 | 0.79 | CASR (0.47) | CASRMEN1KMT2A | |
| SCHEMBL29829733 | 0.77 | TLR8 (0.48) | CASRPDE6DPDE4BTLR8TP53 | |
| SCHEMBL29411941 | 0.76 | BRD4 (0.52) | TP53SIGMAR1KDM4ELMNAHTT | |
| SCHEMBL29829962 | 0.74 | TLR8 (0.45) | CASRTLR8TP53KDM4ENPY1R | |
| SCHEMBL28901986 | 0.72 | MEN1 (0.58) | CASRPDE6DKDM4ELMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111978301-B | Benzimidazole compound with endothelial lipase inhibition effect and application thereof | 盐城师范学院 | 2022-08-02 | — | — | CN | disclosed |