Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 4/20 | 0.60 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PDE6D | O43924 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29829518 | 0.94 | CASR (0.60) | CASRTLR8HPGDALDH1A1KDM4E | |
| SCHEMBL29829974 | 0.93 | CASR (0.53) | CASRTLR8HPGDALDH1A1KDM4E | |
| SCHEMBL29829544 | 0.87 | CASR (0.49) | CASRTLR8HPGDALDH1A1KDM4E | |
| SCHEMBL29829733 | 0.85 | TLR8 (0.48) | CASRTLR8HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL29829696 | 0.84 | TLR8 (0.51) | CASRTLR8SIGMAR1MAPTMEN1 | |
| SCHEMBL29829962 | 0.79 | TLR8 (0.45) | CASRTLR8HPGDALDH1A1KDM4E | |
| SCHEMBL29829509 | 0.78 | TLR8 (0.44) | CASRTLR8HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL29830059 | 0.78 | CASR (0.51) | CASRTLR8HPGDALDH1A1KDM4E | |
| SCHEMBL28480003 | 0.75 | BRD4 (0.57) | HPGDALDH1A1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL29829648 | 0.72 | CASR (0.47) | CASRTLR8HPGDALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111978301-B | Benzimidazole compound with endothelial lipase inhibition effect and application thereof | 盐城师范学院 | 2022-08-02 | — | — | CN | disclosed |