Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 8/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 3/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | SCN1A | P35498 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.34 |
| ▸ | SGK1 | O00141 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | HAT1 | O14929 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23610293 | 1.00 | PIK3CA (0.37) | PIK3CAPIK3R1KITMTORPIK3CD | |
| SCHEMBL23610282 | 0.94 | MAPT (0.39) | SGK1MAPTALDH1A1KDRHAT1 | |
| SCHEMBL29829916 | 0.94 | MAPT (0.39) | SGK1MAPTALDH1A1KDRHAT1 | |
| SCHEMBL29829927 | 0.88 | SLC40A1 (0.38) | PIK3CAPIK3CDPIK3CBPIK3CGSGK1 | |
| SCHEMBL29829671 | 0.88 | ACLY (0.34) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL21596704 | 0.88 | ACLY (0.34) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL21596699 | 0.88 | SLC40A1 (0.38) | PIK3CAPIK3CDPIK3CBPIK3CGSGK1 | |
| SCHEMBL21596668 | 0.88 | CYP2C9 (0.34) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL23610276 | 0.88 | MAPT (0.41) | PIK3CAPIK3R1KITSGK1MAPT | |
| SCHEMBL29829463 | 0.88 | MAPT (0.41) | PIK3CAPIK3R1KITSGK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112469710-B | Pyridyl and pyrazinyl- (aza) indole sulfonamides | 优时比制药有限公司 | 2024-05-14 | — | — | CN | claimed |
| EP-3810591-B1 | PYRIDINYL AND PYRAZINYL-(AZA)INDOLSULFONAMIDES | UCB PHARMA GMBH (DE) | 2022-08-10 | — | — | EP | claimed |
| CN-112469710-B | Pyridyl and pyrazinyl- (aza) indole sulfonamides | 优时比制药有限公司 | 2024-05-14 | — | — | CN | disclosed |