Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRG | P62508 | 4/20 | 0.59 |
| ▸ | PRSS12 | P56730 | 7/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | SERPINE1 | P05121 | 4/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.49 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL420763 | 0.83 | PRSS12 (0.69) | ESRRGPRSS12TP53SMN1; SMN2SERPINE1 | |
| SCHEMBL20764032 | 0.81 | ESRRG (0.79) | ESRRGPRSS12TP53SMN1; SMN2ESR1 | |
| SCHEMBL1307881 | 0.79 | KCNMA1 (0.68) | TP53SMN1; SMN2SERPINE1AKR1C4AKR1C3 | |
| SCHEMBL6830546 | 0.77 | KMT2A (0.53) | SMN1; SMN2SERPINE1AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL14855607 | 0.77 | KCNMA1 (0.65) | PRSS12TP53SMN1; SMN2SERPINE1AKR1C4 | |
| SCHEMBL1309948 | 0.74 | AKR1C4 (0.60) | TP53SMN1; SMN2SERPINE1AKR1C4AKR1C3 | |
| SCHEMBL20764060 | 0.74 | ESRRG (1.00) | ESRRGTP53SMN1; SMN2ESR1 | |
| SCHEMBL14855933 | 0.74 | KCNMA1 (0.65) | TP53SMN1; SMN2SERPINE1AKR1C4AKR1C3 | |
| SCHEMBL5844175 | 0.74 | HPGD (0.66) | ESRRGTP53SMN1; SMN2 | |
| SCHEMBL5950326 | 0.74 | GRIK1 (0.80) | PRSS12SMN1; SMN2SERPINE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4039276-A1 | INHIBITOR AGAINST EXPRESSION OF IMMUNE CHECKPOINT MOLECULE | Renascience Inc. (JP) | 2022-08-10 | — | — | EP | disclosed |