Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 17/20 | 0.58 |
| ▸ | JAK2 | O60674 | 7/20 | 0.45 |
| ▸ | JAK3 | P52333 | 6/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18419034 | 0.93 | JAK1 (0.48) | JAK1JAK2JAK3GPR119 | |
| SCHEMBL17500887 | 0.89 | JAK1 (0.49) | JAK1JAK2JAK3GPR119 | |
| SCHEMBL17500886 | 0.89 | JAK1 (0.49) | JAK1JAK2JAK3GPR119 | |
| SCHEMBL15970552 | 0.89 | JAK1 (0.47) | JAK1JAK2JAK3GPR119 | |
| SCHEMBL15970551 | 0.89 | JAK1 (0.47) | JAK1JAK2JAK3GPR119 | |
| SCHEMBL21373227 | 0.88 | JAK1 (0.45) | JAK1JAK2JAK3 | |
| SCHEMBL21434743 | 0.88 | JAK1 (0.45) | JAK1JAK2JAK3 | |
| SCHEMBL21434744 | 0.88 | JAK1 (0.45) | JAK1JAK2JAK3 | |
| SCHEMBL10226760 | 0.87 | GPR119 (0.45) | JAK1JAK2JAK3GPR119 | |
| SCHEMBL2732774 | 0.85 | GPR119 (0.42) | JAK1JAK2JAK3GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3543241-B1 | PREPARATION METHOD FOR AND INTERMEDIATE OF PYRROLO SIX-MEMBERED HETEROAROMATIC RING DERIVATIVE | JIANGSU HENGRUI MEDICINE CO (CN) | 2022-09-07 | — | — | EP | disclosed |