Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.42 |
| ▸ | JAK1 | P23458 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18419034 | 0.90 | JAK1 (0.48) | GPR119JAK1JAK2HTR6CYP2C9 | |
| SCHEMBL10226760 | 0.88 | GPR119 (0.45) | GPR119JAK1JAK2HTR6CYP2C9 | |
| SCHEMBL29838827 | 0.85 | JAK1 (0.58) | GPR119JAK1JAK2JAK3 | |
| SCHEMBL19757372 | 0.84 | GPR119 (0.47) | GPR119JAK1JAK2JAK3 | |
| SCHEMBL17545914 | 0.82 | HTR6 (0.42) | GPR119JAK1JAK2HTR6BCHE | |
| SCHEMBL29711905 | 0.81 | GPR119 (0.43) | GPR119JAK1JAK2HTR6CYP2C9 | |
| SCHEMBL15970531 | 0.81 | GPR119 (0.45) | GPR119JAK1JAK2HTR6CYP2C9 | |
| SCHEMBL15970530 | 0.81 | GPR119 (0.45) | GPR119JAK1JAK2HTR6CYP2C9 | |
| SCHEMBL17500887 | 0.81 | JAK1 (0.49) | GPR119JAK1JAK2JAK3 | |
| SCHEMBL17500886 | 0.81 | JAK1 (0.49) | GPR119JAK1JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632898-A1 | HETEROCYCLIC TYROSINE KINASE INHIBITORS | Biogen Idec MA Inc. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058645-A1 | HETEROCYCLIC TYROSINE KINASE INHIBITORS | BIOGEN IDEC MA INC. (US) | 2012-05-03 | — | — | WO | disclosed |