Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.51 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.48 |
| ▸ | CDK9 | P50750 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31505996 | 1.00 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1CYP19A1CYP1A2CYP3A4 | |
| SCHEMBL23943387 | 0.86 | KDM1A (0.46) | CYP1A2CYP3A4ALDH1A1CYP2D6CDK9 | |
| SCHEMBL27346672 | 0.83 | CYP1A2 (0.67) | CYP19A1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| SCHEMBL31011660 | 0.83 | PDGFRB (0.41) | HSP90AA1HSP90AB1CYP19A1ALDH1A1PDGFRB | |
| SCHEMBL3625797 | 0.83 | CDK9 (0.44) | CYP1A2CYP3A4ALDH1A1CYP2D6CDK9 | |
| SCHEMBL3600353 | 0.81 | IDH1 (0.45) | HSP90AA1HSP90AB1CYP1A2ALDH1A1CDK9 | |
| SCHEMBL31011570 | 0.81 | IDH1 (0.45) | HSP90AA1HSP90AB1CYP1A2ALDH1A1CDK9 | |
| SCHEMBL1033197 | 0.81 | ALDH1A1 (0.55) | ALDH1A1USP2HSD17B10SMN1; SMN2KDM4E | |
| SCHEMBL3362587 | 0.80 | HSP90AA1 (0.60) | HSP90AA1HSP90AB1CYP19A1CYP1A2CYP3A4 | |
| SCHEMBL30507329 | 0.80 | HSP90AA1 (0.60) | HSP90AA1HSP90AB1CYP19A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260001846-A1 | SPIROCYCLOHEXANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS ANTI-APOPTOTIC INHIBITORS | SERVIER LAB (FR) | 2026-01-01 | — | — | US | disclosed |
| EP-4551566-A1 | NEW SPIROCYCLOHEXANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS ANTI-APOPTOTIC INHIBITORS | Les Laboratoires Servier (FR) | 2025-05-14 | — | — | EP | disclosed |
| WO-2024008941-A1 | NEW SPIROCYCLOHEXANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS ANTI-APOPTOTIC INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2024-01-11 | — | — | WO | disclosed |
| WO-2024008941-A1 | NEW SPIROCYCLOHEXANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS ANTI-APOPTOTIC INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2024-01-11 | — | — | WO | disclosed |
| CN-107739370-B | Preparation method and application of pyrrolidone BRD4 protein inhibitor | 中国药科大学 | 2021-03-30 | — | — | CN | disclosed |
| EP-2137163-B1 | INHIBITORS OF PROTEIN KINASES | ASTRAZENECA AB (SE) | 2015-03-18 | — | — | EP | disclosed |
| EP-2137163-B1 | INHIBITORS OF PROTEIN KINASES | ASTRAZENECA AB (SE) | 2015-03-18 | — | — | EP | disclosed |
| US-20150011576-A1 | Inhibitors of Protein Kinases | ASTRAZENECA AB (SE) | 2015-01-08 | — | — | US | disclosed |
| US-20150011576-A1 | Inhibitors of Protein Kinases | ASTRAZENECA AB (SE) | 2015-01-08 | — | — | US | disclosed |
| US-20150011576-A1 | Inhibitors of Protein Kinases | ASTRAZENECA AB (SE) | 2015-01-08 | — | — | US | disclosed |
| US-20100184789-A1 | INHIBITORS OF PROTEIN KINASES | ASTRAZENECA AB (SE) | 2010-07-22 | — | — | US | disclosed |
| US-20100184789-A1 | INHIBITORS OF PROTEIN KINASES | ASTRAZENECA AB (SE) | 2010-07-22 | — | — | US | disclosed |
| US-20100184789-A1 | INHIBITORS OF PROTEIN KINASES | ASTRAZENECA AB (SE) | 2010-07-22 | — | — | US | disclosed |
| US-20100168144-A1 | INHIBITORS OF PROTEIN KINASES | ASTRAZENECA AB (SE) | 2010-07-01 | — | — | US | disclosed |
| US-20100168144-A1 | INHIBITORS OF PROTEIN KINASES | ASTRAZENECA AB (SE) | 2010-07-01 | — | — | US | disclosed |
| US-20100168144-A1 | INHIBITORS OF PROTEIN KINASES | ASTRAZENECA AB (SE) | 2010-07-01 | — | — | US | disclosed |
| EP-2137165-A1 | INHIBITORS OF PROTEIN KINASES | Ingenium Pharmaceuticals GmbH (DE) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008129071-A1 | INHIBITORS OF PROTEIN KINASES | INGENIUM PHARMACEUTICALS GMBH (DE) | 2008-10-30 | — | — | WO | disclosed |
| WO-2008129071-A1 | INHIBITORS OF PROTEIN KINASES | INGENIUM PHARMACEUTICALS GMBH (DE) | 2008-10-30 | — | — | WO | disclosed |
| WO-2008129070-A1 | INHIBITORS OF PROTEIN KINASES | INGENIUM PHARMACEUTICALS GMBH (DE) | 2008-10-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150011576-A1 | Inhibitors of Protein Kinases | CDK1, CDK2, CDK5 | HSP90AA1 666/4885HSP90AB1 660/4885CYP19A1 3004/4885 |
| US-20260001846-A1 | SPIROCYCLOHEXANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS ANTI-APOPTOTIC INHIBITORS | BCL2, BCL2A1, BAX | HSP90AA1 293/4885HSP90AB1 195/4885CYP19A1 1947/4885 |
| US-20100184789-A1 | INHIBITORS OF PROTEIN KINASES | CDK1, CDK2, CDK5 | HSP90AA1 666/4885HSP90AB1 660/4885CYP19A1 3004/4885 |
| US-20100168144-A1 | INHIBITORS OF PROTEIN KINASES | CDK1, CDK2, CCNI | HSP90AA1 676/4885HSP90AB1 657/4885CYP19A1 1814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.