Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 17/20 | 0.39 |
| ▸ | KRAS | P01116 | 9/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27186138 | 1.00 | SOS1 (0.39) | SOS1KRASLIPGPDE10APPARG | |
| SCHEMBL27186137 | 1.00 | SOS1 (0.39) | SOS1KRASLIPGPDE10APPARG | |
| SCHEMBL27186112 | 0.81 | SOS1 (0.42) | SOS1KRAS | |
| SCHEMBL27186120 | 0.81 | SOS1 (0.42) | SOS1KRAS | |
| SCHEMBL29844219 | 0.81 | SOS1 (0.42) | SOS1KRAS | |
| SCHEMBL27186280 | 0.75 | KRAS (0.47) | SOS1KRAS | |
| SCHEMBL27186284 | 0.75 | KRAS (0.47) | SOS1KRAS | |
| SCHEMBL27186103 | 0.69 | CECR2 (0.36) | — | |
| SCHEMBL27186295 | 0.68 | PIM3 (0.39) | — | |
| SCHEMBL30853318 | 0.68 | BTK (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117651701-A | Novel substituted bicyclic aza heterocycles as SOS1 inhibitors | 唯久生物技术(苏州)有限公司 | 2024-03-05 | — | — | CN | disclosed |
| WO-2022187266-A1 | NOVEL SUBSTITUTED BICYCLI AZA-HETEROCYCLES AS SOS1 INHIBITORS | VIVA STAR BIOSCIENCES (SUZHOU) CO., LTD. (CN) | 2022-09-09 | — | — | WO | disclosed |