Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | PDE5A | O76074 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.48 |
| ▸ | TNF | P01375 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | WNT3A | P56704 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23529687 | 1.00 | MEN1 (0.54) | MEN1KMT2APDE5AKDM4EALDH1A1 | |
| SCHEMBL15820514 | 0.86 | NPC1 (0.47) | MEN1KMT2APDE5AKDM4EALDH1A1 | |
| SCHEMBL29844513 | 0.81 | MEN1 (0.55) | MEN1KMT2APDE5AKDM4EALDH1A1 | |
| SCHEMBL23560586 | 0.81 | MEN1 (0.55) | MEN1KMT2APDE5AKDM4EALDH1A1 | |
| SCHEMBL29929742 | 0.77 | WNT3A (0.43) | PDE5AKDM4EALDH1A1HPGDPOLB | |
| SCHEMBL28631850 | 0.77 | WNT3A (0.43) | PDE5AKDM4EALDH1A1HPGDPOLB | |
| SCHEMBL1715696 | 0.76 | NPC1 (0.58) | PDE5AKDM4EALDH1A1HPGDPOLB | |
| SCHEMBL18300154 | 0.76 | HTT (0.52) | MEN1KMT2APDE5APOLBDYRK1A | |
| SCHEMBL27201465 | 0.75 | MEN1 (0.53) | MEN1KMT2APDE5APOLBDYRK1A | |
| SCHEMBL509566 | 0.74 | EGFR (0.64) | MEN1KMT2AKDM4EPOLBCLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113004284-B | Tetracyclic compounds as plasma kallikrein inhibitors and uses thereof | 成都康弘药业集团股份有限公司 | 2022-08-12 | — | — | CN | disclosed |
| CN-113004286-B | Tricyclic compounds as plasma kallikrein inhibitors and uses thereof | 成都康弘药业集团股份有限公司 | 2022-08-12 | — | — | CN | disclosed |