Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT3A | P56704 | 5/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.39 |
| ▸ | VNN1 | O95497 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29929742 | 1.00 | WNT3A (0.43) | WNT3AJAK2TYK2DYRK1ACLK4 | |
| SCHEMBL28652017 | 0.82 | WNT3A (0.53) | WNT3AJAK2TYK2DYRK1ACLK4 | |
| SCHEMBL15820514 | 0.80 | NPC1 (0.47) | WNT3ADYRK1ACLK4KDM4EALDH1A1 | |
| SCHEMBL23529687 | 0.77 | MEN1 (0.54) | WNT3ADYRK1ACLK4KDM4EMAPT | |
| SCHEMBL29844533 | 0.77 | MEN1 (0.54) | WNT3ADYRK1ACLK4KDM4EMAPT | |
| SCHEMBL29929873 | 0.77 | PDE5A (0.50) | WNT3AJAK2TYK2DYRK1ACLK4 | |
| SCHEMBL28925081 | 0.76 | MAP4K1 (0.43) | DYRK1AALDH1A1MAPK1HSD17B10 | |
| SCHEMBL28635707 | 0.75 | MAP4K1 (0.43) | TYK2ALDH1A1MAPK14 | |
| SCHEMBL18300154 | 0.71 | HTT (0.52) | WNT3ADYRK1ACLK4MAPTL3MBTL1 | |
| SCHEMBL1715696 | 0.70 | NPC1 (0.58) | DYRK1ACLK4KDM4EMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115244050-B | Novel HPK1 inhibitor and preparation method and application thereof | 轶诺(浙江)药业有限公司 | 2024-06-21 | — | — | CN | disclosed |
| CN-115244050-A | Novel HPK1 inhibitor and preparation method and application thereof | 轶诺(浙江)药业有限公司 | 2022-10-25 | — | — | CN | disclosed |
| CN-113336747-A | Novel HPK1 inhibitor and preparation method and application thereof | 轶诺(浙江)药业有限公司 | 2021-09-03 | — | — | CN | disclosed |