Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 5/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | LIPG | Q9Y5X9 | 6/20 | 0.41 |
| ▸ | LPL | P06858 | 5/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | P4HB | P07237 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | F11 | P03951 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18241343 | 1.00 | HIF1A (0.43) | HIF1AROCK1LIPGLPLAAK1 | |
| SCHEMBL20505406 | 0.90 | HIF1A (0.41) | HIF1AROCK1LIPGLPLAAK1 | |
| SCHEMBL22408495 | 0.89 | HIF1A (0.43) | HIF1AROCK1LIPGLPLDGAT1 | |
| SCHEMBL31032443 | 0.89 | HIF1A (0.43) | HIF1AROCK1LIPGLPLDGAT1 | |
| SCHEMBL20561876 | 0.88 | ROCK1 (0.41) | HIF1AROCK1LIPGLPLAAK1 | |
| SCHEMBL424108 | 0.87 | HSD17B10 (0.44) | HIF1AROCK1LIPGLPLDGAT1 | |
| SCHEMBL20504699 | 0.84 | LPL (0.42) | HIF1AROCK1LIPGLPLAAK1 | |
| SCHEMBL18241209 | 0.84 | HIF1A (0.42) | HIF1AROCK1LIPGAAK1PRSS1 | |
| SCHEMBL3204011 | 0.82 | L3MBTL1 (0.52) | HIF1ALIPGAAK1DGAT1GLA | |
| SCHEMBL16898733 | 0.82 | HIF1A (0.44) | HIF1ALIPGLPLAAK1DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11446298-B2 | Pyrimidine derivatives | IDORSIA PHARMACEUTICALS LTD (CH) | 2022-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11446298-B2 | Pyrimidine derivatives | PTGER1, PTGER4, PTGER2 | HIF1A 1110/4885ROCK1 3476/4885LIPG 4502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.