Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MLYCD | O95822 | 4/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18650131 | 0.87 | KMT2A (0.50) | MEN1KMT2AMLYCDHDAC1HDAC6 | |
| SCHEMBL21590176 | 0.82 | MLYCD (0.45) | MLYCDHDAC1HDAC6POLBALDH1A1 | |
| SCHEMBL395688 | 0.81 | MLYCD (0.51) | MEN1KMT2AMLYCDHDAC1HDAC6 | |
| SCHEMBL340978 | 0.81 | HDAC1 (0.47) | MEN1KMT2AMLYCDHDAC1HDAC6 | |
| SCHEMBL22858842 | 0.81 | MLYCD (0.44) | MLYCDHDAC1HDAC6 | |
| SCHEMBL22858843 | 0.80 | MLYCD (0.43) | MEN1KMT2AMLYCDHDAC1HDAC6 | |
| SCHEMBL11210779 | 0.78 | KMT2A (0.56) | MEN1KMT2AMLYCDHDAC1HDAC6 | |
| SCHEMBL31246466 | 0.77 | KMT2A (0.59) | MEN1KMT2AHDAC1HDAC6ALDH1A1 | |
| SCHEMBL15933416 | 0.77 | MAPK1 (0.56) | MEN1KMT2ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL13543234 | 0.76 | KMT2A (0.47) | MEN1KMT2AMLYCDHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115073474-B | Pyrrolo [2,3-b ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2024-10-18 | — | — | CN | disclosed |
| WO-2022253311-A1 | HPK1 INHIBITOR AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-12-08 | — | — | WO | disclosed |
| CN-115433184-A | HPK1 inhibitor and application thereof | 武汉人福创新药物研发中心有限公司 | 2022-12-06 | — | — | CN | disclosed |
| CN-115028639-A | Pyrrolo [2,3-b ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2022-09-09 | — | — | CN | disclosed |