Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.70 |
| ▸ | BRD4 | O60885 | 3/20 | 0.70 |
| ▸ | EGFR | P00533 | 2/20 | 0.57 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.55 |
| ▸ | JAK3 | P52333 | 1/20 | 0.54 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.53 |
| ▸ | CDK4 | P11802 | 5/20 | 0.52 |
| ▸ | CCND1 | P24385 | 2/20 | 0.52 |
| ▸ | CCND2 | P30279 | 2/20 | 0.52 |
| ▸ | CCND3 | P30281 | 2/20 | 0.52 |
| ▸ | AURKA | O14965 | 3/20 | 0.52 |
| ▸ | TTK | P33981 | 1/20 | 0.51 |
| ▸ | JUN | P05412 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16514362 | 1.00 | JAK2 (0.70) | JAK2BRD4EGFRMAP4K1FGFR1 | |
| SCHEMBL16514799 | 0.89 | JAK2 (0.66) | JAK2BRD4EGFRFGFR2CDK4 | |
| SCHEMBL16513630 | 0.89 | JAK2 (0.56) | JAK2BRD4EGFRMAP4K1FGFR1 | |
| SCHEMBL29847837 | 0.89 | JAK2 (0.56) | JAK2BRD4EGFRMAP4K1FGFR1 | |
| SCHEMBL16514760 | 0.88 | JAK2 (0.56) | JAK2BRD4EGFRFGFR1FGFR2 | |
| SCHEMBL29847922 | 0.88 | JAK2 (0.56) | JAK2BRD4EGFRFGFR1FGFR2 | |
| SCHEMBL16515483 | 0.88 | FGFR2 (0.71) | JAK2BRD4EGFRFGFR1KDR | |
| SCHEMBL29848096 | 0.88 | FGFR2 (0.71) | JAK2BRD4EGFRFGFR1KDR | |
| SCHEMBL16823187 | 0.88 | JAK2 (0.56) | JAK2BRD4EGFRMAP4K1FGFR1 | |
| SCHEMBL16513407 | 0.87 | BRD4 (0.59) | JAK2BRD4EGFRMAP4K1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109851617-B | Chemical entities, compositions, and methods | 润新生物公司 | 2022-08-16 | — | — | CN | disclosed |