Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.56 |
| ▸ | BRD4 | O60885 | 3/20 | 0.56 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.54 |
| ▸ | JUN | P05412 | 4/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | CDK4 | P11802 | 5/20 | 0.52 |
| ▸ | CCND1 | P24385 | 5/20 | 0.52 |
| ▸ | CDK2 | P24941 | 5/20 | 0.52 |
| ▸ | CDK1 | P06493 | 3/20 | 0.52 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.52 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.52 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.50 |
| ▸ | TTK | P33981 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 2/20 | 0.49 |
| ▸ | BRD2 | P25440 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16514760 | 1.00 | JAK2 (0.56) | JAK2BRD4PTK2JUNMAPK8 | |
| SCHEMBL16514799 | 0.89 | JAK2 (0.66) | JAK2BRD4PTK2JUNMAPK8 | |
| SCHEMBL16513553 | 0.89 | JUN (0.66) | JAK2BRD4PTK2JUNMAPK8 | |
| SCHEMBL16514469 | 0.89 | WEE1 (0.48) | JAK2BRD4PTK2JUNMAPK8 | |
| SCHEMBL29848219 | 0.89 | WEE1 (0.48) | JAK2BRD4PTK2JUNMAPK8 | |
| SCHEMBL16514362 | 0.88 | JAK2 (0.70) | JAK2BRD4JUNMAPK8MAPK10 | |
| SCHEMBL16514398 | 0.88 | JAK2 (0.56) | JAK2BRD4PTK2JUNMAPK8 | |
| SCHEMBL29846917 | 0.88 | JAK2 (0.70) | JAK2BRD4JUNMAPK8MAPK10 | |
| SCHEMBL29847770 | 0.88 | JAK2 (0.56) | JAK2BRD4PTK2JUNMAPK8 | |
| SCHEMBL29847708 | 0.88 | JAK2 (0.56) | JAK2BRD4PTK2JUNMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109851617-B | Chemical entities, compositions, and methods | 润新生物公司 | 2022-08-16 | — | — | CN | disclosed |