Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 9/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | GPR6 | P46095 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | VEGFA | P15692 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23753850 | 1.00 | TBK1 (0.40) | TBK1ARAKR1A1AKR1B1JAK2 | |
| SCHEMBL22470577 | 0.88 | TBK1 (0.44) | TBK1JAK2IKBKE | |
| SCHEMBL29847085 | 0.88 | TBK1 (0.44) | TBK1JAK2IKBKE | |
| SCHEMBL23099080 | 0.85 | CHRM4 (0.43) | TBK1ARIKBKEEPAS1CHRM4 | |
| SCHEMBL22470817 | 0.85 | TBK1 (0.51) | TBK1IKBKE | |
| SCHEMBL29847200 | 0.85 | TBK1 (0.51) | TBK1IKBKE | |
| SCHEMBL22470606 | 0.83 | XDH (0.47) | TBK1ARIKBKEEPAS1CHRM4 | |
| SCHEMBL4426792 | 0.81 | XDH (0.46) | TBK1ARIKBKEEPAS1CHRM4 | |
| SCHEMBL14977113 | 0.81 | TBK1 (0.40) | TBK1JAK2IKBKE | |
| SCHEMBL16075152 | 0.81 | SYK (0.40) | TBK1ARJAK2IKBKE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115135648-B | Dihydronaphthyridones, preparation method and medical application thereof | 劲方医药科技(上海)有限公司 | 2024-02-09 | — | — | CN | disclosed |
| CN-115135648-A | Dihydronaphthyridinone compounds, preparation method and medical application thereof | 劲方医药科技(上海)有限公司 | 2022-09-30 | — | — | CN | disclosed |