Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 2/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.33 |
| ▸ | PDE2A | O00408 | 5/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.31 |
| ▸ | FEN1 | P39748 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.31 |
| ▸ | IDH1 | O75874 | 4/20 | 0.31 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23753939 | 1.00 | KCNN4 (0.36) | KCNN4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL23753929 | 0.85 | PDE2A (0.33) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL29846857 | 0.85 | PDE2A (0.33) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL29846973 | 0.84 | GRM5 (0.38) | KCNN4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL23753820 | 0.78 | FFAR1 (0.35) | KCNN4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL29846957 | 0.78 | FFAR1 (0.35) | KCNN4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL29847050 | 0.78 | HSD17B13 (0.34) | KCNN4PDE2A | |
| SCHEMBL22470689 | 0.78 | HSD17B13 (0.34) | KCNN4PDE2A | |
| SCHEMBL23753819 | 0.77 | PIK3CG (0.37) | KCNN4ALOX5APFEN1 | |
| SCHEMBL29847015 | 0.77 | PIK3CG (0.37) | KCNN4ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115135648-B | Dihydronaphthyridones, preparation method and medical application thereof | 劲方医药科技(上海)有限公司 | 2024-02-09 | — | — | CN | disclosed |
| CN-115135648-A | Dihydronaphthyridinone compounds, preparation method and medical application thereof | 劲方医药科技(上海)有限公司 | 2022-09-30 | — | — | CN | disclosed |