Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PDE5A | O76074 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 3/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.48 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29060167 | 1.00 | HTT (0.55) | HTTEGFRPOLBNR2F2LMNA | |
| SCHEMBL19305769 | 0.87 | HTT (0.55) | HTTEGFRPOLBNR2F2LMNA | |
| SCHEMBL29059871 | 0.83 | HTT (0.49) | HTTEGFRPOLBNR2F2LMNA | |
| SCHEMBL29849114 | 0.83 | HTT (0.49) | HTTEGFRPOLBNR2F2LMNA | |
| SCHEMBL29956286 | 0.82 | EGFR (0.50) | HTTEGFRNR2F2LMNAALDH1A1 | |
| SCHEMBL24096410 | 0.81 | CA1 (0.50) | HTTEGFRPOLBNR2F2ALDH1A1 | |
| SCHEMBL29634669 | 0.80 | HTT (0.58) | HTTEGFRPOLBNR2F2LMNA | |
| SCHEMBL5233252 | 0.80 | HTT (0.58) | HTTEGFRPOLBNR2F2LMNA | |
| SCHEMBL16781105 | 0.79 | LMNA (0.58) | HTTEGFRPOLBNR2F2LMNA | |
| SCHEMBL20061415 | 0.79 | HTT (0.54) | HTTEGFRPOLBNR2F2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116669738-A | Pyrimidopyridone derivative as SOS1 inhibitor, and preparation method and application thereof | 苏州阿尔脉生物科技有限公司 | 2023-08-29 | — | — | CN | disclosed |
| WO-2022170802-A1 | PYRIMIDO-PYRIDONE DERIVATIVE AS SOS1 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 苏州阿尔脉生物科技有限公司 | 2022-08-18 | — | — | WO | disclosed |