Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | DAO | P14920 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28840648 | 1.00 | NPC1 (0.51) | NPC1RAB9AKDM4EHKDC1TDP1 | |
| SCHEMBL4420731 | 0.85 | NPC1 (0.58) | NPC1RAB9AKDM4EHKDC1TDP1 | |
| SCHEMBL3735091 | 0.84 | NPC1 (0.38) | NPC1RAB9AKDM4EHKDC1TDP1 | |
| SCHEMBL28840596 | 0.81 | RAB9A (0.40) | NPC1RAB9AKDM4EHKDC1TDP1 | |
| SCHEMBL29852050 | 0.81 | RAB9A (0.40) | NPC1RAB9AKDM4EHKDC1TDP1 | |
| SCHEMBL352444 | 0.81 | NPC1 (0.53) | NPC1RAB9AKDM4EHKDC1TDP1 | |
| SCHEMBL8980162 | 0.79 | KDM4E (0.47) | NPC1RAB9AKDM4EHKDC1TDP1 | |
| SCHEMBL8980270 | 0.77 | NPC1 (0.53) | NPC1RAB9AKDM4EHKDC1TDP1 | |
| SCHEMBL3741920 | 0.77 | NPC1 (0.38) | NPC1RAB9AKDM4EHKDC1TDP1 | |
| SCHEMBL8980355 | 0.76 | TSHR (0.49) | NPC1RAB9AKDM4EHKDC1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116867758-A | IRAK degradation agents and uses thereof | 凯麦拉医疗公司 | 2023-10-10 | — | — | CN | disclosed |
| CN-116133692-A | Methods of treating mutant lymphomas | 凯麦拉医疗公司 | 2023-05-16 | — | — | CN | disclosed |
| CN-115052627-A | IRAK degrading agents and uses thereof | 凯麦拉医疗公司 | 2022-09-13 | — | — | CN | disclosed |