Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30672824 | 0.88 | KMT2A (0.55) | PDE4BKMT2AKDM4EMEN1LMNA | |
| SCHEMBL2962849 | 0.77 | KMT2A (0.53) | KMT2AKDM4EMEN1LMNADDR2 | |
| SCHEMBL2428083 | 0.74 | MEN1 (0.62) | PDE4BKMT2AKDM4EMEN1LMNA | |
| SCHEMBL9019380 | 0.73 | DDR2 (0.60) | KMT2AKDM4EMEN1LMNADDR2 | |
| SCHEMBL7192591 | 0.71 | GAA (0.57) | KMT2AKDM4EMEN1LMNATP53 | |
| SCHEMBL10824754 | 0.71 | CA12 (0.41) | PDE4BKMT2AKDM4EMEN1LMNA | |
| SCHEMBL9284220 | 0.71 | MAPT (0.56) | KMT2AKDM4ETP53ALDH1A1MAPT | |
| SCHEMBL11883140 | 0.70 | CA12 (0.37) | KMT2AKDM4EMEN1LMNACA12 | |
| SCHEMBL8630309 | 0.70 | KMT2A (0.52) | KMT2AKDM4EMEN1LMNADDR2 | |
| SCHEMBL31511844 | 0.69 | KMT2A (0.51) | KMT2AKDM4EMEN1LMNADDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7837981-B2 | Methods for imaging soluble A-beta | GENERAL ELECTRIC COMPANY (US) | 2010-11-23 | — | — | US | disclosed |
| EP-1631561-B1 | COMPOSITIONS AND METHODS FOR NON-INVASIVE IMAGING OF SOLUBLE BETA-AMYLOID | GEN ELECTRIC (US) | 2010-08-18 | — | — | EP | disclosed |
| US-7727511-B2 | Agents for imaging soluble a-beta | GENERAL ELECTRIC COMPANY (US) | 2010-06-01 | — | — | US | disclosed |
| US-20070189967-A1 | AGENTS FOR IMAGING SOLUBLE A-BETA | GENERAL ELECTRIC COMPANY (US) | 2007-08-16 | — | — | US | disclosed |
| US-20070140960-A1 | METHODS FOR IMAGING SOLUBLE A-BETA | GENERAL ELECTRIC COMPANY (US) | 2007-06-21 | — | — | US | disclosed |
| EP-1631561-A2 | COMPOSITIONS AND METHODS FOR NON-INVASIVE IMAGING OF SOLUBLE BETA-AMYLOID | GENERAL ELECTRIC COMPANY (US) | 2006-03-08 | — | — | EP | disclosed |
| WO-2004100998-A2 | COMPOSITIONS AND METHODS FOR NON-INVASIVE IMAGING OF SOLUBLE BETA-AMYLOID | GENERAL ELECTRIC COMPANY (US) | 2004-11-25 | — | — | WO | disclosed |
| US-20040223909-A1 | Compositions and methods for non-invasive imaging of soluble beta-amyloid | GENERAL ELECTRIC COMPANY | 2004-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040223909-A1 | Compositions and methods for non-invasive imaging of soluble beta-amyloid | APP, APBA1, BACE1 | PDE4B 1622/4885KMT2A 4551/4885KDM4E 4841/4885 |
| US-20070140960-A1 | METHODS FOR IMAGING SOLUBLE A-BETA | APBA1, APP, FABP7 | PDE4B 1590/4885KMT2A 4355/4885KDM4E 4759/4885 |
| US-20070189967-A1 | AGENTS FOR IMAGING SOLUBLE A-BETA | APBA1, APP, FABP7 | PDE4B 1438/4885KMT2A 4536/4885KDM4E 4807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.