SCHEMBL29853151

SCHEMBL29853151

CCOC(=O)CCc1ccccc1OCc1ccc2c(-c3cccc(CN)c3)cccc2c1

nearest known ligand 0.50

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CFD P00746 6/20 0.50
F11 P03951 2/20 0.50
TPSB2 P20231 2/20 0.50
PLG P00747 1/20 0.50
PLAU P00749 1/20 0.50
KLKB1 P03952 1/20 0.50
F7 P08709 1/20 0.50
PTGER1 P34995 3/20 0.45
PTGER4 P35408 3/20 0.45
PTGER3 P43115 3/20 0.45
PTGER2 P43116 3/20 0.45
FFAR1 O14842 2/20 0.42
FFAR4 Q5NUL3 1/20 0.41
GPR34 Q9UPC5 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23218546 1.00 CFD (0.50) CFDF11TPSB2PLGPLAU
SCHEMBL23218032 0.91 CFD (0.57) CFDF11TPSB2PLGPLAU
SCHEMBL29853168 0.91 CFD (0.57) CFDF11TPSB2PLGPLAU
SCHEMBL29592466 0.88 CFD (0.60) CFDF11TPSB2PLGPLAU
SCHEMBL23218166 0.88 CFD (0.60) CFDF11TPSB2PLGPLAU
SCHEMBL23218835 0.84 CFD (0.57) CFDF11TPSB2PLGPLAU
SCHEMBL29852891 0.84 CFD (0.57) CFDF11TPSB2PLGPLAU
SCHEMBL23218442 0.83 CFD (0.46) CFDF11TPSB2PLGPLAU
SCHEMBL29852467 0.83 CFD (0.46) CFDF11TPSB2PLGPLAU
SCHEMBL23229103 0.82 CFD (0.46) CFDF11TPSB2PLGPLAU

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4041238-A1 ORAL COMPLEMENT FACTOR D INHIBITORS Biocryst Pharmaceuticals, Inc. (US) 2022-08-17 EP disclosed