Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 5/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 8/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29856008 | 0.93 | ADAMTS5 (0.53) | ADAMTS5KDM4EALOX12HSP90AA1NPC1 | |
| SCHEMBL29856117 | 0.93 | ADAMTS5 (0.53) | ADAMTS5KDM4EALOX12HSP90AA1NPC1 | |
| SCHEMBL29856059 | 0.92 | ADAMTS5 (0.52) | ADAMTS5KDM4EALOX12HSP90AA1NPC1 | |
| SCHEMBL27196522 | 0.92 | ADAMTS5 (0.52) | ADAMTS5KDM4EALOX12HSP90AA1NPC1 | |
| Ammonia Solution, Strong SCHEMBL27196502 | 0.91 | ADAMTS5 (0.51) | ADAMTS5KDM4EALOX12HSP90AA1NPC1 | |
| SCHEMBL24634712 | 0.90 | HSP90AA1 (0.58) | ADAMTS5KDM4EALOX12HSP90AA1NPC1 | |
| SCHEMBL30876601 | 0.90 | HSP90AA1 (0.58) | ADAMTS5KDM4EALOX12HSP90AA1NPC1 | |
| SCHEMBL30876742 | 0.84 | ADAMTS5 (0.60) | ADAMTS5KDM4EALOX12SMN1; SMN2L3MBTL1 | |
| SCHEMBL24634659 | 0.84 | ADAMTS5 (0.60) | ADAMTS5KDM4EALOX12SMN1; SMN2L3MBTL1 | |
| SCHEMBL29855894 | 0.81 | HTT (0.49) | ADAMTS5KDM4EALOX12HSP90AA1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4288416-A2 | SMALL MOLECULE INHIBITORS OF GRP78 AND USES THEREOF | The Regents Of The University Of Michigan (US) | 2023-12-13 | — | — | EP | disclosed |
| WO-2022169834-A2 | SMALL MOLECULE INHIBITORS OF GRP78 AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2022-08-11 | — | — | WO | disclosed |