Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 9/20 | 0.58 |
| ▸ | RAB9A | P51151 | 9/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.58 |
| ▸ | NPC1 | O15118 | 6/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.58 |
| ▸ | KDM1A | O60341 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.57 |
| ▸ | LMNA | P02545 | 6/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.57 |
| ▸ | MITF | O75030 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 7/20 | 0.56 |
| ▸ | HTT | P42858 | 6/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30876601 | 1.00 | HSP90AA1 (0.58) | HSP90AA1RAB9AKMT2ANPC1L3MBTL1 | |
| SCHEMBL27196522 | 0.91 | ADAMTS5 (0.52) | HSP90AA1RAB9AKMT2ANPC1L3MBTL1 | |
| SCHEMBL29856059 | 0.91 | ADAMTS5 (0.52) | HSP90AA1RAB9AKMT2ANPC1L3MBTL1 | |
| Ammonia Solution, Strong SCHEMBL27196502 | 0.90 | ADAMTS5 (0.51) | HSP90AA1RAB9AKMT2ANPC1L3MBTL1 | |
| SCHEMBL29856008 | 0.90 | ADAMTS5 (0.53) | HSP90AA1RAB9AKMT2ANPC1L3MBTL1 | |
| SCHEMBL29856117 | 0.90 | ADAMTS5 (0.53) | HSP90AA1RAB9AKMT2ANPC1L3MBTL1 | |
| SCHEMBL29856096 | 0.90 | ADAMTS5 (0.51) | HSP90AA1RAB9AKMT2ANPC1L3MBTL1 | |
| SCHEMBL24634759 | 0.89 | KDM1A (0.72) | HSP90AA1RAB9AKMT2ANPC1L3MBTL1 | |
| SCHEMBL30876584 | 0.89 | KDM1A (0.72) | HSP90AA1RAB9AKMT2ANPC1L3MBTL1 | |
| SCHEMBL24634753 | 0.89 | ADAMTS5 (0.63) | HSP90AA1RAB9AKMT2ANPC1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240124419-A1 | SMALL MOLECULE INHIBITORS OF GRP78 AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2024-04-18 | — | — | US | disclosed |
| WO-2022169834-A2 | SMALL MOLECULE INHIBITORS OF GRP78 AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2022-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240124419-A1 | SMALL MOLECULE INHIBITORS OF GRP78 AND USES THEREOF | HSPA5, HSPA2, PSMG3 | HSP90AA1 26/4885RAB9A 2566/4885KMT2A 4365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.