Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 6/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ADAMTS5 | Q9UNA0 | 6/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27196452 | 1.00 | HTT (0.54) | HTTKMT2ASMN1; SMN2MEN1HSP90AA1 | |
| SCHEMBL27196497 | 0.93 | HTT (0.53) | HTTKMT2ASMN1; SMN2MEN1HSP90AA1 | |
| SCHEMBL29856037 | 0.93 | HTT (0.53) | HTTKMT2ASMN1; SMN2MEN1HSP90AA1 | |
| SCHEMBL24634613 | 0.86 | HTT (0.66) | HTTKMT2ASMN1; SMN2MEN1HSP90AA1 | |
| SCHEMBL30876696 | 0.86 | HTT (0.66) | HTTKMT2ASMN1; SMN2MEN1HSP90AA1 | |
| SCHEMBL29856009 | 0.84 | KMT2A (0.64) | HTTKMT2ASMN1; SMN2MEN1HSP90AA1 | |
| SCHEMBL29856092 | 0.83 | KMT2A (0.51) | HTTKMT2ASMN1; SMN2MEN1HSP90AA1 | |
| SCHEMBL24634664 | 0.83 | HTT (0.61) | HTTKMT2ASMN1; SMN2MEN1HSP90AA1 | |
| SCHEMBL30876579 | 0.83 | HTT (0.61) | HTTKMT2ASMN1; SMN2MEN1HSP90AA1 | |
| SCHEMBL24634702 | 0.83 | HTT (0.61) | HTTKMT2ASMN1; SMN2MEN1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4288416-A2 | SMALL MOLECULE INHIBITORS OF GRP78 AND USES THEREOF | The Regents Of The University Of Michigan (US) | 2023-12-13 | — | — | EP | disclosed |
| WO-2022169834-A2 | SMALL MOLECULE INHIBITORS OF GRP78 AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2022-08-11 | — | — | WO | disclosed |