Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 5/20 | 0.44 |
| ▸ | NOS3 | P29474 | 4/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5925793 | 0.79 | MAPK14 (0.47) | NOS2NOS3NOS1NAPRTLTA4H | |
| SCHEMBL16728957 | 0.79 | NOS3 (0.48) | NOS2NOS3NOS1CSF1RNAPRT | |
| SCHEMBL18188367 | 0.78 | GRM5 (0.49) | KDM4EALDH1A1CYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL6025094 | 0.77 | PTPN1 (0.42) | NOS2NOS3NOS1TLR8CSF1R | |
| SCHEMBL510673 | 0.76 | NOS3 (0.45) | NOS2NOS3NOS1CSF1RNAPRT | |
| SCHEMBL24693564 | 0.75 | KDM4E (0.45) | NPC1RAB9AKDM4EALDH1A1CYP2D6 | |
| SCHEMBL23269104 | 0.74 | NOS3 (0.44) | NOS2NOS3NOS1CSF1RNAPRT | |
| SCHEMBL624629 | 0.73 | FFAR1 (0.47) | NOS2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL3978730 | 0.72 | CYP3A4 (0.55) | TLR8NPC1KDM4EALDH1A1CYP2C19 | |
| SCHEMBL18952028 | 0.72 | MAPT (0.57) | NOS2NOS3NOS1NAPRTLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022169974-A1 | INHIBITORS OF URAT1 AND PHARMACEUTICAL USES THEREOF | NEXYS THERAPEUTICS, INC. (US) | 2022-08-11 | — | — | WO | disclosed |