Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29856145 | 0.85 | POLB (0.51) | POLBNTRK1HTTMAPTCNR2 | |
| SCHEMBL10645570 | 0.81 | POLB (0.73) | POLBHTTNPSR1MAPTKMT2A | |
| SCHEMBL12486373 | 0.76 | DYRK1A (0.53) | POLBNTRK1MAPTCNR2NFATC1 | |
| SCHEMBL29856428 | 0.76 | NTRK1 (0.46) | POLBNTRK1CNR2NFATC1GSK3B | |
| SCHEMBL29856369 | 0.76 | SLC22A12 (0.48) | POLBNTRK1NPSR1MAPTCNR2 | |
| SCHEMBL29856335 | 0.76 | NTRK1 (0.40) | POLBNTRK1MAPTCNR2NFATC1 | |
| SCHEMBL22558992 | 0.75 | DYRK1A (0.51) | POLBNTRK1HTTNPSR1MAPT | |
| SCHEMBL31022899 | 0.75 | DYRK1A (0.51) | POLBNTRK1HTTNPSR1MAPT | |
| SCHEMBL20223640 | 0.72 | DYRK1A (0.49) | POLBNTRK1HTTNPSR1MAPT | |
| SCHEMBL31720261 | 0.72 | CYP11B1 (0.52) | CYP11B1CYP11B2HTTNPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022169974-A1 | INHIBITORS OF URAT1 AND PHARMACEUTICAL USES THEREOF | NEXYS THERAPEUTICS, INC. (US) | 2022-08-11 | — | — | WO | disclosed |