Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | LIG1 | P18858 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29856320 | 0.85 | POLB (0.48) | POLBNTRK1DYRK1ANFATC1GSK3B | |
| SCHEMBL29856369 | 0.82 | SLC22A12 (0.48) | POLBNTRK1DYRK1ANFATC1GSK3B | |
| SCHEMBL29856428 | 0.82 | NTRK1 (0.46) | POLBNTRK1DYRK1ANFATC1GSK3B | |
| SCHEMBL12486373 | 0.79 | DYRK1A (0.53) | POLBNTRK1DYRK1ANFATC1GSK3B | |
| SCHEMBL22558992 | 0.78 | DYRK1A (0.51) | POLBNTRK1DYRK1ANFATC1GSK3B | |
| SCHEMBL31022899 | 0.78 | DYRK1A (0.51) | POLBNTRK1DYRK1ANFATC1GSK3B | |
| SCHEMBL29856503 | 0.76 | ADORA3 (0.44) | POLBMAPTESR1ESR2LMNA | |
| SCHEMBL20223640 | 0.75 | DYRK1A (0.49) | POLBNTRK1DYRK1ANFATC1GSK3B | |
| SCHEMBL29856313 | 0.74 | DYRK1A (0.55) | NTRK1DYRK1AGSK3BCNR2CNR1 | |
| SCHEMBL29856214 | 0.72 | KDM5A (0.40) | MAPTESR1ESR2LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022169974-A1 | INHIBITORS OF URAT1 AND PHARMACEUTICAL USES THEREOF | NEXYS THERAPEUTICS, INC. (US) | 2022-08-11 | — | — | WO | disclosed |