Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.81 |
| ▸ | RAB9A | P51151 | 9/20 | 0.81 |
| ▸ | TP53 | P04637 | 8/20 | 0.81 |
| ▸ | NFKB1 | P19838 | 7/20 | 0.81 |
| ▸ | NFKB2 | Q00653 | 7/20 | 0.81 |
| ▸ | RELA | Q04206 | 7/20 | 0.81 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.81 |
| ▸ | MAPT | P10636 | 5/20 | 0.81 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.81 |
| ▸ | NPC1 | O15118 | 7/20 | 0.77 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.67 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3430034 | 1.00 | SMN1; SMN2 (0.81) | SMN1; SMN2RAB9ATP53NFKB1NFKB2 | |
| SCHEMBL28653242 | 0.90 | SMN1; SMN2 (1.00) | SMN1; SMN2RAB9ATP53NFKB1NFKB2 | |
| SCHEMBL26095666 | 0.83 | MAPT (0.72) | SMN1; SMN2RAB9ATP53NFKB1NFKB2 | |
| SCHEMBL2810636 | 0.82 | NR1H4 (1.00) | SMN1; SMN2RAB9ATP53NFKB1NFKB2 | |
| SCHEMBL29449760 | 0.82 | NR1H4 (0.85) | SMN1; SMN2RAB9ATP53NFKB1NFKB2 | |
| SCHEMBL11714014 | 0.79 | MAPT (0.68) | SMN1; SMN2RAB9ATP53NFKB1NFKB2 | |
| SCHEMBL28925303 | 0.77 | SMN1; SMN2 (0.77) | SMN1; SMN2RAB9ATP53NFKB1NFKB2 | |
| SCHEMBL25863479 | 0.76 | SMN1; SMN2 (0.59) | SMN1; SMN2RAB9ATP53NFKB1NFKB2 | |
| SCHEMBL23524022 | 0.74 | SMN1; SMN2 (0.57) | SMN1; SMN2RAB9ATP53NFKB1NFKB2 | |
| SCHEMBL25856751 | 0.74 | SMN1; SMN2 (0.57) | SMN1; SMN2RAB9ATP53NFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117377478-A | Methods and compositions for regenerating hair cells in the inner ear of an adult mammal | 麻省眼耳科医院 | 2024-01-09 | — | — | CN | disclosed |
| EP-4288066-A1 | METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS IN THE INNER EAR OF ADULT MAMMALS | Massachusetts Eye and Ear Infirmary (US) | 2023-12-13 | — | — | EP | disclosed |
| WO-2022169881-A1 | METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS IN THE INNER EAR OF ADULT MAMMALS | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 2022-08-11 | — | — | WO | disclosed |