SCHEMBL26095666

SCHEMBL26095666

COc1ccc(-c2noc(-c3ccccc3Br)n2)cc1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 12/20 0.72
▸ LMNA P02545 1/20 0.72
▸ RAB9A P51151 11/20 0.72
▸ NPC1 O15118 10/20 0.72
▸ SMN1; SMN2 Q16637 9/20 0.72
▸ TP53 P04637 9/20 0.72
▸ NFKB1 P19838 4/20 0.72
▸ NFKB2 Q00653 4/20 0.72
▸ RELA Q04206 4/20 0.72
▸ L3MBTL1 Q9Y468 3/20 0.72
▸ MAPK1 P28482 2/20 0.72
▸ NR1H4 Q96RI1 2/20 0.71
▸ S1PR1 P21453 1/20 0.71
▸ HSD17B10 Q99714 2/20 0.63
▸ RXFP1 Q9HBX9 2/20 0.63
▸ NPSR1 Q6W5P4 1/20 0.62
▸ MEN1 O00255 2/20 0.59
▸ KMT2A Q03164 2/20 0.59
▸ THRB P10828 1/20 0.58
▸ POLB P06746 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29859163 0.83 SMN1; SMN2 (0.81) MAPTRAB9ANPC1SMN1; SMN2TP53
SCHEMBL3430034 0.83 SMN1; SMN2 (0.81) MAPTRAB9ANPC1SMN1; SMN2TP53
SCHEMBL7291752 0.83 NR1H4 (1.00) MAPTLMNARAB9ANPC1SMN1; SMN2
SCHEMBL6697420 0.83 NR1H4 (1.00) MAPTLMNARAB9ANPC1SMN1; SMN2
SCHEMBL28653242 0.83 SMN1; SMN2 (1.00) MAPTLMNARAB9ANPC1SMN1; SMN2
SCHEMBL12895918 0.80 RAB9A (0.76) MAPTLMNARAB9ANPC1SMN1; SMN2
SCHEMBL24212403 0.78 NR1H4 (1.00) MAPTLMNARAB9ANPC1SMN1; SMN2
SCHEMBL11733051 0.78 MAPT (0.68) MAPTLMNARAB9ANPC1SMN1; SMN2
SCHEMBL12692350 0.77 NPC1 (0.86) MAPTLMNARAB9ANPC1SMN1; SMN2
SCHEMBL22757148 0.76 NR1H4 (0.78) MAPTLMNARAB9ANPC1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250228242-A1 PROTEIN AGGREGATION INHIBITING COMPOUNDS FOR PLANT DISEASE CONTROL MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2025-07-17 — — US claimed
EP-4173485-A1 PROTEIN AGGREGATION INHIBITING COMPOUNDS FOR PLANT DISEASE CONTROL Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2023-05-03 — — EP claimed
US-20250228242-A1 PROTEIN AGGREGATION INHIBITING COMPOUNDS FOR PLANT DISEASE CONTROL MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2025-07-17 — — US disclosed
WO-2023073115-A1 PROTEIN AGGREGATION INHIBITING COMPOUNDS FOR PLANT DISEASE CONTROL MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2023-05-04 — — WO disclosed
EP-4173485-A1 PROTEIN AGGREGATION INHIBITING COMPOUNDS FOR PLANT DISEASE CONTROL Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2023-05-03 — — EP disclosed
EP-4173485-A1 PROTEIN AGGREGATION INHIBITING COMPOUNDS FOR PLANT DISEASE CONTROL Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2023-05-03 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250228242-A1 PROTEIN AGGREGATION INHIBITING COMPOUNDS FOR PLANT DISEASE CONTROL APP, APBA1, PRNP MAPT 8/4885LMNA 3101/4885RAB9A 1693/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback