Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.53 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.35 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29859578 | 0.98 | PDPK1 (0.51) | PDPK1ARPDE4BPDE7APDE7B | |
| SCHEMBL29859838 | 0.75 | PDPK1 (0.49) | PDPK1ARTSHRHTTDAO | |
| SCHEMBL31297662 | 0.74 | PDPK1 (0.65) | PDPK1TSHRHTTDAOLMNA | |
| SCHEMBL29859617 | 0.70 | PDPK1 (0.47) | PDPK1PDE4BPDE7ATSHRLMNA | |
| SCHEMBL22144475 | 0.69 | PDPK1 (0.62) | PDPK1TSHRHTTDAOLMNA | |
| SCHEMBL7302300 | 0.69 | PDPK1 (0.62) | PDPK1TSHRHTTDAOSMN1; SMN2 | |
| SCHEMBL29859817 | 0.69 | PDPK1 (0.46) | PDPK1PDE4BPDE7ATSHRLMNA | |
| SCHEMBL5462003 | 0.66 | PDPK1 (0.57) | PDPK1DAOHPGD | |
| SCHEMBL801810 | 0.65 | PDE4B (0.34) | PDE4BPDE7APDE7BELANERAB9A | |
| SCHEMBL988816 | 0.62 | PDPK1 (0.50) | PDPK1TSHRHTTDAOHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116888127-A | Tri-fused ring HPK1 inhibitor and application thereof | 轩竹生物科技股份有限公司 | 2023-10-13 | — | — | CN | disclosed |
| WO-2022188823-A1 | TRICYCLIC HPK1 INHIBITOR AND USE THEREOF | 山东轩竹医药科技有限公司 | 2022-09-15 | — | — | WO | disclosed |