Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | SRC | P12931 | 2/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | PI4KA | P42356 | 1/20 | 0.33 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.33 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23326642 | 1.00 | EGFR (0.35) | EGFRSRCFGFR1FGFR2FGFR4 | |
| SCHEMBL29861403 | 0.81 | HSD17B10 (0.33) | CYP1A2TSHRHSD17B10CYP2C9SLC22A12 | |
| SCHEMBL23326744 | 0.81 | HSD17B10 (0.33) | CYP1A2TSHRHSD17B10CYP2C9SLC22A12 | |
| SCHEMBL24672007 | 0.81 | SLC22A12 (0.39) | SRCCYP1A2TSHRHSD17B10CYP2C9 | |
| SCHEMBL23326542 | 0.77 | TLR7 (0.36) | EGFRSRCFGFR1FGFR2FGFR4 | |
| SCHEMBL29910281 | 0.77 | TLR7 (0.36) | EGFRSRCFGFR1FGFR2FGFR4 | |
| SCHEMBL29861603 | 0.76 | CYP1A2 (0.38) | CYP1A2TSHRCYP2C9CYP3A4HPGD | |
| SCHEMBL23326451 | 0.76 | CYP1A2 (0.38) | CYP1A2TSHRCYP2C9CYP3A4HPGD | |
| SCHEMBL12410481 | 0.74 | SELE (0.35) | SRCHSD17B10SLC22A12PI4KAPI4K2B | |
| SCHEMBL17148436 | 0.73 | SELE (0.34) | SRCSLC22A12PI4KAPI4K2BPI4K2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4055017-A1 | BICYCLIC HETEROARYL COMPOUNDS AND USES THEREOF | Revolution Medicines, Inc. (US) | 2022-09-14 | — | — | EP | disclosed |
| CN-114901662-A | Bicyclic heteroaryl compounds and uses thereof | 锐新医药公司 | 2022-08-12 | — | — | CN | disclosed |